Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4676 PA5014 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase glnE, PA5014 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008882Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. GO:0047388Catalysis of the reaction: [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP. +47 total
0.478 No Hit N/A —
4677 PA4932 50S ribosomal protein L9 PA4932, rplI AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0019843Binding to a ribosomal RNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
0.478 Hit 47.9% 1.49e-06
4678 PA4846 3-dehydroquinate dehydratase PA4846, aroQ1, aroQ Experimental + AlphaFold
4.2.1.10
GO:0003855Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). +25 total
0.478 No Hit N/A —
4679 PA0925 hypothetical protein PA0925 AlphaFold – – 0.478 No Hit N/A —
4680 PA0245 3-dehydroquinate dehydratase PA0245, aroQ2 AlphaFold
4.2.1.10
GO:0003855Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). +25 total
0.478 No Hit N/A —
4681 PA0143 nonspecific ribonucleoside hydrolase PA0143, nuh AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008477Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose. GO:0045437Catalysis of the reaction: H2O + uridine = ribofuranose + uracil. +36 total
0.478 No Hit N/A —
4682 PA5239 transcription termination factor Rho PA5239, rho AlphaFold
3.6.4.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008186Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. +69 total
0.477 No Hit N/A —
4683 PA4793 hypothetical protein PA4793 AlphaFold – – 0.477 No Hit N/A —
4684 PA3745 30S ribosomal protein S16 rpsP, PA3745 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0015935The smaller of the two subunits of a ribosome. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
0.477 Hit 40.0% 6.87e-16
4685 PA2754 hypothetical protein PA2754 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043022Binding to a ribosome.
0.477 No Hit N/A —
4686 PA2113 pyroglutatmate porin OpdO PA2113, opdO Experimental + AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.477 No Hit N/A —
4687 PA4730 pantoate--beta-alanine ligase PA4730, panC AlphaFold
6.3.2.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004592Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. +14 total
0.476 No Hit N/A —
4688 PA3303a hypothetical protein ColabFold – – 0.476 No Hit N/A —
4689 PA3068 NAD-specific glutamate dehydrogenase gdhB, PA3068 AlphaFold
1.4.1.2
GO:0004352Catalysis of the reaction: L-glutamate + NAD+ + H2O = 2-oxoglutarate + NH4+ + NADH + H+. GO:0004069Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. GO:0006538The chemical reactions and pathways resulting in the breakdown of L-glutamate. +14 total
0.476 No Hit N/A —
4690 PA3059 pellicle/biofilm biosynthesis glycosyltransferase PelF PA3059, pelF AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
0.476 No Hit N/A —
4691 PA2951 electron transfer flavoprotein subunit alpha etfA, PA2951 AlphaFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0033539A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
0.476 Hit 97.1% 2.33e-15
4692 PA1956 hypothetical protein fapA, PA1956 AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:1990000The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins.
0.476 No Hit N/A —
4693 PA1804 DNA-binding protein HU PA1804, hupB AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:1990103A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC. GO:1990178A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure. +69 total
0.476 No Hit N/A —
4694 PA1486 hypothetical protein PA1486 AlphaFold –
GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.
0.476 No Hit N/A —
4695 PA4417 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase PA4417, murE AlphaFold
6.3.2.13
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. +811 total
0.475 No Hit N/A —
4696 PA2049 hypothetical protein ColabFold – – 0.474 No Hit N/A —
4697 PA1388 hypothetical protein PA1388 AlphaFold – – 0.474 No Hit N/A —
4698 PA0656 HIT family protein PA0656 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043530Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester. +25 total
0.474 Hit 50.9% 2.60e-14
4699 PA4868 urease subunit alpha PA4868, ureC AlphaFold
3.5.1.5
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016151Binding to a nickel (Ni) cation. GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. +47 total
0.473 No Hit N/A —
4700 PA3566 hypothetical protein PA3566 Experimental + AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.473 No Hit N/A —
Page of 223 · 5572 total proteins