Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4626 PA3519 hypothetical protein PA3519 AlphaFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.491 No Hit N/A —
4627 PA2496 hypothetical protein PA2496 AlphaFold –
GO:0046872Binding to a metal ion.
0.491 No Hit N/A —
4628 PA1728 hypothetical protein PA1728 AlphaFold – – 0.491 No Hit N/A —
4629 PA2031 hypothetical protein PA2031 AlphaFold – – 0.49 No Hit N/A —
4630 PA1953 hypothetical protein fapD, PA1953 AlphaFold
3.4.22.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.49 No Hit N/A —
4631 PA3571 transcriptional regulator MmsR PA3571, mmsR AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:2000284Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process. +25 total
0.489 No Hit N/A —
4632 PA0157 resistance-nodulation-cell division (RND) efflux membrane fusion protein PA0157 AlphaFold –
GO:1990281A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
0.489 No Hit N/A —
4633 PA4761 molecular chaperone DnaK dnaK, PA4761 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +1013 total
0.488 Hit 68.8% 9.30e-37
4634 PA3614 hypothetical protein PA3614 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.
0.488 Hit 38.5% 8.36e-10
4635 PA1372 hypothetical protein PA1372 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033202A protein complex that possesses DNA helicase activity. GO:0043138Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. +47 total
0.488 No Hit N/A —
4636 PA1052 hypothetical protein PA1052 AlphaFold –
GO:0043798Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP. GO:0008887Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. GO:0031388The process of introducing one or more phosphate groups into an organic acid.
0.488 No Hit N/A —
4637 PA2778 hypothetical protein PA2778 AlphaFold –
GO:0005515Binding to a protein.
0.487 No Hit N/A —
4638 PA5450 ABC transporter PA5450, wzt AlphaFold –
GO:0035796A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP. GO:0070258A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. +58 total
0.486 Hit 29.2% 1.77e-09
4639 PA2992 hypothetical protein PA2992 AlphaFold – – 0.486 No Hit N/A —
4640 PA2964 4-amino-4-deoxychorismate lyase PA2964, pabC Experimental + AlphaFold
4.1.3.38
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008696Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H+ + pyruvate. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +36 total
0.486 No Hit N/A —
4641 PA2080 kynureninase KynU PA2080, kynU AlphaFold
3.7.1.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0030429Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine + H+. Also acts on 3'-hydroxykynurenine and some other (3-arylcarbonyl)- alanines. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +710 total
0.486 Hit 26.6% 5.58e-36
4642 PA1942 hypothetical protein PA1942 AlphaFold – – 0.486 No Hit N/A —
4643 PA4695 acetolactate synthase small subunit ilvH, PA4695 AlphaFold
2.2.1.6
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003984Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. GO:1990610Binds to and modulates the activity of acetolactate synthase. +36 total
0.485 No Hit N/A —
4644 PA3813 scaffold protein iscU, PA3813 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0008198Binding to a ferrous iron ion, Fe(II). +47 total
0.485 Hit 76.2% 5.86e-58
4645 PA3505 L-aspartate dehydrogenase nadX, PA3505 AlphaFold
1.4.1.21
GO:0033735Catalysis of the reaction: Catalysis of the reaction: L-aspartate + NAD(P)+ + H2O = oxaloacetate + NH4+ + NADPH + H+. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +36 total
0.485 No Hit N/A —
4646 PA3177 hypothetical protein PA3177 AlphaFold
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species. +14 total
0.485 No Hit N/A —
4647 PA2546 ring-cleaving dioxygenase PA2546 AlphaFold –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
0.485 Hit 27.9% 5.04e-09
4648 PA2205 hypothetical protein PA2205 AlphaFold – – 0.485 No Hit N/A —
4649 PA1156 ribonucleotide-diphosphate reductase subunit alpha PA1156, nrdA Experimental + AlphaFold
1.17.4.1
GO:0005971An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004748Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. +25 total
0.485 Hit 50.9% 2.35e-30
4650 PA2464 hypothetical protein PA2464 AlphaFold – – 0.484 No Hit N/A —
Page of 223 · 5572 total proteins