Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4951 PA1393 adenylyl-sulfate kinase cysC, PA1393 AlphaFold
2.7.1.25
GO:0004020Catalysis of the reaction: adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0070814The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. +14 total
0.388 Hit 50.0% 1.66e-47
4952 PA5320 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase PA5320, coaBC, coaC AlphaFold –
GO:0071513A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0046872Binding to a metal ion. +58 total
0.387 Hit 31.4% 1.84e-20
4953 PA4686 hypothetical protein PA4686 AlphaFold – – 0.387 No Hit N/A —
4954 PA3158 UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase PA3158, wbpB, wlbA Experimental + AlphaFold
1.1.1.335
GO:0070403Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. GO:0070404Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. GO:0003954Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. +912 total
0.387 No Hit N/A —
4955 PA1583 succinate dehydrogenase flavoprotein subunit sdhA, PA1583 AlphaFold
1.3.5.1
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +710 total
0.387 Hit 62.8% 2.28e-119
4956 PA1106 hypothetical protein PA1106 AlphaFold – – 0.387 No Hit N/A —
4957 PA0912 hypothetical protein PA0912 AlphaFold – – 0.387 No Hit N/A —
4958 PA4913 ABC transporter PA4913 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0015818The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015820The directed movement of L-leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.386 No Hit N/A —
4959 PA0604 ABC transporter PA0604 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0019810Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. GO:0019809Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. +14 total
0.386 No Hit N/A —
4960 PA3016 hypothetical protein PA3016 AlphaFold – – 0.385 No Hit N/A —
4961 PA5435 pyruvate carboxylase subunit B PA5435 AlphaFold –
GO:0008948Catalysis of the reaction: H+ + oxaloacetate = CO2 + pyruvate. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.384 Hit 48.4% 1.50e-10
4962 PA2292 hypothetical protein PA2292 AlphaFold –
GO:0046872Binding to a metal ion.
0.384 No Hit N/A —
4963 PA1781 assimilatory nitrite reductase large subunit PA1781, nirB AlphaFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +811 total
0.383 Hit 31.1% 3.16e-25
4964 PA4488 hypothetical protein PA4488 AlphaFold – – 0.381 No Hit N/A —
4965 PA4483 aspartyl/glutamyl-tRNA amidotransferase subunit A PA4483, gatA Experimental + AlphaFold
6.3.5.7
GO:0030956A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0050567Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. +25 total
0.381 Hit 42.4% 7.98e-57
4966 PA3972 acyl-CoA dehydrogenase PA3972 AlphaFold –
GO:0003995Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
0.381 Hit 27.7% 1.79e-14
4967 PA2759 hypothetical protein PA2759 AlphaFold – – 0.381 No Hit N/A —
4968 PA2565 hypothetical protein PA2565 AlphaFold – – 0.381 No Hit N/A —
4969 PA1390 glycosyl transferase family protein PA1390 AlphaFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
0.381 No Hit N/A —
4970 PA4321 hypothetical protein PA4321 AlphaFold – – 0.38 No Hit N/A —
4971 PA1417 hypothetical protein PA1417 AlphaFold –
GO:0005948A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate. GO:0003984Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +58 total
0.38 Hit 38.0% 1.33e-09
4972 PA0440 oxidoreductase PA0440 AlphaFold
1.3.1.1
GO:0004159Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.38 Hit 34.4% 1.34e-60
4973 PA4837 hypothetical protein cntO, zrmA, PA4837 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015344Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0038023Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. +58 total
0.379 No Hit N/A —
4974 PA4703 hypothetical protein PA4703 AlphaFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.379 No Hit N/A —
4975 PA4249 30S ribosomal protein S8 rpsH, PA4249 AlphaFold –
GO:0022627The small subunit of a ribosome located in the cytosol. GO:0019843Binding to a ribosomal RNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
0.379 Hit 26.4% 5.42e-06
Page of 223 · 5572 total proteins