Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4926 PA0849 thioredoxin reductase PA0849, trxB2 AlphaFold
1.8.1.9
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004791Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. +25 total
0.4 Hit 32.0% 1.77e-06
4927 PA5270 hypothetical protein PA5270 AlphaFold – – 0.399 No Hit N/A —
4928 PA2657 two-component response regulator carR, PA2657 Experimental + AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +58 total
0.399 No Hit N/A —
4929 PA4642 hypothetical protein PA4642 AlphaFold – – 0.398 No Hit N/A —
4930 PA1011 hypothetical protein PA1011 AlphaFold – – 0.398 No Hit N/A —
4931 PA5037 hypothetical protein PA5037 AlphaFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
0.397 No Hit N/A —
4932 PA4542 chaperone protein ClpB clpB, PA4542 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
0.397 Hit 40.6% 9.97e-53
4933 PA3618 hypothetical protein PA3618 AlphaFold – – 0.397 No Hit N/A —
4934 PA5436 acetyl-CoA carboxylase subunit alpha PA5436 AlphaFold –
GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004075Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. +47 total
0.396 Hit 68.8% 2.44e-09
4935 PA3687 phosphoenolpyruvate carboxylase PA3687, ppc AlphaFold
4.1.1.31
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000287Binding to a magnesium (Mg) ion. GO:0008964Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-. +47 total
0.396 No Hit N/A —
4936 PA1873 hypothetical protein PA1873 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050897Binding to a cobalt ion (Co2+). GO:0015087Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other. +69 total
0.396 No Hit N/A —
4937 PA1606 hypothetical protein PA1606 Experimental + AlphaFold – – 0.396 No Hit N/A —
4938 PA1012 hypothetical protein PA1012 AlphaFold – – 0.396 No Hit N/A —
4939 PA4755 transcription elongation factor GreA PA4755, greA AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0070063Binding to an RNA polymerase molecule or complex. GO:0006354The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. +14 total
0.393 No Hit N/A —
4940 PA3521 hypothetical protein PA3521 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +25 total
0.393 No Hit N/A —
4941 PA0355 protease PfpI PA0355, pfpI Experimental + AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019172Catalysis of the reaction: methylglyoxal + H2O = D-lactate. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +69 total
0.393 Hit 28.6% 5.30e-11
4942 PA0425 multidrug resistance protein MexA mexA, PA0425 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0042802Binding to an identical protein or proteins. +710 total
0.392 No Hit N/A —
4943 PA1973 coenzyme PQQ synthesis protein F PA1973, pqqF AlphaFold
3.4.24.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +58 total
0.391 Hit 34.0% 1.73e-19
4944 PA1481 cytochrome c-type biogenesis protein CcmG ccmG, dsbE, PA1481 Experimental + AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. +25 total
0.391 No Hit N/A —
4945 PA1447 flagellar biosynthesis protein FliQ fliQ, PA1447 AlphaFold –
GO:0009425One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0044780The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. +25 total
0.391 No Hit N/A —
4946 PA0397 cation efflux system protein PA0397 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0005385Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. +58 total
0.391 Hit 43.2% 7.32e-20
4947 PA2118 O6-methylguanine-DNA methyltransferase ada, PA2118 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003908Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +710 total
0.39 Hit 30.9% 8.64e-11
4948 PA0154 protocatechuate 3,4-dioxygenase subunit alpha PA0154, pcaG AlphaFold –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate. GO:0008199Binding to a ferric iron ion, Fe(III). GO:0018578Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate. +58 total
0.39 No Hit N/A —
4949 PA1185 glutathione S-transferase PA1185 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
0.389 Hit 28.8% 8.73e-08
4950 PA0201 hypothetical protein PA0201 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.389 No Hit N/A —
Page of 223 · 5572 total proteins