Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5001 PA2723 hypothetical protein PA2723 Experimental + AlphaFold –
GO:0046872Binding to a metal ion.
0.369 No Hit N/A —
5002 PA2272 penicillin-binding protein 3A pbpC, PA2272 AlphaFold
3.4.16.4
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0008955Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+. +811 total
0.369 No Hit N/A —
5003 PA1788 hypothetical protein PA1788 AlphaFold – – 0.369 No Hit N/A —
5004 PA0437 cytosine deaminase PA0437, codA AlphaFold –
GO:0004131Catalysis of the reaction: cytosine + H2O = uracil + NH4+. GO:0035888Catalysis of the reaction: H+ + H2O + isoguanine = NH4+ + xanthine. GO:0046872Binding to a metal ion. +25 total
0.369 No Hit N/A —
5005 PA0532 hypothetical protein PA0532 AlphaFold – – 0.368 No Hit N/A —
5006 PA4912 branched-chain amino acid ABC transporter PA4912 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015188Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid. GO:0015190Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. +1114 total
0.367 No Hit N/A —
5007 PA3178 hypothetical protein PA3178 AlphaFold – – 0.367 No Hit N/A —
5008 PA2666 6-carboxytetrahydropterin synthase QueD PA2666 Experimental + AlphaFold
4.-.-.-
GO:0070497Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+. GO:0046872Binding to a metal ion. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.
0.367 Hit 30.8% 3.16e-15
5009 PA0668 tyrosine--tRNA ligase tyrZ ColabFold –
GO:0006437The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.367 Hit 30.8% 2.55e-22
5010 PA5010 UDP-glucose:(heptosyl) LPS alpha 1,3-glucosyltransferase WaaG PA5010, waaG Experimental + AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.
0.366 No Hit N/A —
5011 PA1655 glutathione S-transferase PA1655 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004364Catalysis of the reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H+.
0.366 Hit 33.1% 1.66e-13
5012 PA1425 ABC transporter ATP-binding protein PA1425 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.366 Hit 37.2% 1.44e-07
5013 PA4966 hypothetical protein PA4966 AlphaFold – – 0.365 No Hit N/A —
5014 PA3224 hypothetical protein PA3224 AlphaFold – – 0.365 No Hit N/A —
5015 PA5408 hypothetical protein PA5408 AlphaFold – – 0.364 No Hit N/A —
5016 PA4568 50S ribosomal protein L21 rplU, PA4568 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990904A macromolecular complex that contains both RNA and protein molecules. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +47 total
0.364 No Hit N/A —
5017 PA4506 peptide ABC transporter ATP-binding protein PA4506 AlphaFold
7.4.2.9
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +47 total
0.364 Hit 34.8% 3.72e-19
5018 PA4148 short-chain dehydrogenase PA4148 AlphaFold –
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.364 Hit 43.5% 1.00e-08
5019 PA1690 translocation protein in type III secretion pscU, PA1690 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.364 No Hit N/A —
5020 PA5524 short-chain dehydrogenase PA5524 AlphaFold
1.3.1.58
GO:0018511Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD+ = 2,3-dihydroxy-p-cumate + H+ + NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units.
0.363 Hit 48.3% 3.38e-09
5021 PA5405 hypothetical protein PA5405 AlphaFold – – 0.363 No Hit N/A —
5022 PA1179 two-component response regulator PhoP phoP, PA1179 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +58 total
0.363 No Hit N/A —
5023 PA0266 5-aminovalerate aminotransferase DavT PA0266, davT AlphaFold
2.6.1.48
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0034386Catalysis of the reaction: 2-oxoglutarate + 4-aminobutanoate = L-glutamate + succinate semialdehyde. GO:0047589Catalysis of the reaction: 5-aminopentanoate + 2-oxoglutarate = 5-oxopentanoate + L-glutamate. +710 total
0.363 Hit 35.6% 7.19e-24
5024 PA5241 exopolyphosphatase PA5241, ppx AlphaFold
3.6.1.11 2.7.4.1
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0004309Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. GO:0008976Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). +912 total
0.362 No Hit N/A —
5025 PA4405 hypothetical protein PA4405 AlphaFold – – 0.362 No Hit N/A —
Page of 223 · 5572 total proteins