Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4901 PA2633 hypothetical protein PA2633 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0009306The controlled release of proteins from a cell.
0.41 No Hit N/A —
4902 PA1711 hypothetical protein PA1711, exsE Experimental + AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. +36 total
0.41 No Hit N/A —
4903 PA1182 transcriptional regulator PA1182 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.41 No Hit N/A —
4904 PA0403 bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase PA0403, pyrR AlphaFold –
GO:0004845Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.41 No Hit N/A —
4905 PA1794 glutamine--tRNA ligase glnS, PA1794 Experimental + AlphaFold
6.1.1.18
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004819Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). +811 total
0.408 Hit 70.0% 1.32e-06
4906 PA0145 hypothetical protein PA0145 AlphaFold –
GO:0070694Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil. GO:0009159The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.
0.408 No Hit N/A —
4907 PA5483 two-component response regulator AlgB PA5483, algB AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +1215 total
0.407 No Hit N/A —
4908 PA5465 hypothetical protein PA5465 AlphaFold –
GO:0016846Catalysis of the elimination of hydrogen sulfide or substituted H2S. GO:0046872Binding to a metal ion.
0.407 Hit 39.2% 6.02e-06
4909 PA4485 hypothetical protein rlpA, PA4485 Experimental + AlphaFold
4.2.2.-
GO:0008932Catalysis of the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0000270The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +14 total
0.407 No Hit N/A —
4910 PA2749 DNA-specific endonuclease I PA2749, endA AlphaFold –
GO:0004536Catalysis of the cleavage of ester linkages within deoxyribonucleic acid. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +25 total
0.407 No Hit N/A —
4911 PA2255 paerucumarin biosynthesis protein PvcB pvcB, PA2255 Experimental + AlphaFold
1.14.20.9
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.407 No Hit N/A —
4912 PA1422 protein GbuR PA1422, gbuR AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:1900081Any process that modulates the frequency, rate or extent of arginine catabolic process. +14 total
0.407 No Hit N/A —
4913 PA4603 hypothetical protein PA4603 AlphaFold – – 0.406 No Hit N/A —
4914 PA1002 anthranilate synthase component II PA1002, trpG, phnB AlphaFold
4.1.3.27
GO:0004048Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. GO:0004049Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. GO:0000162The chemical reactions and pathways resulting in the formation of L-tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; L-tryptophan is synthesized from chorismate via anthranilate. +14 total
0.406 Hit 29.8% 6.42e-09
4915 PA5131 2,3-bisphosphoglycerate-independent phosphoglycerate mutase pgm, gpmI, PA5131 AlphaFold
5.4.2.12
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0030145Binding to a manganese ion (Mn). GO:0004619Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate. +69 total
0.405 No Hit N/A —
4916 PA4775 hypothetical protein PA4775 AlphaFold – – 0.404 No Hit N/A —
4917 PA0805 hypothetical protein PA0805 AlphaFold – – 0.404 No Hit N/A —
4918 PA3825 hypothetical protein PA3825 Experimental + AlphaFold
3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:0046872Binding to a metal ion. +25 total
0.403 No Hit N/A —
4919 PA4279 pantothenate kinase coaA, coaX, PA4279 Experimental + AlphaFold
2.7.1.33
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +36 total
0.402 No Hit N/A —
4920 PA3053 hydrolase PA3053 Experimental + AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.402 Hit 40.2% 2.87e-10
4921 PA5278 diaminopimelate epimerase dapF, PA5278 AlphaFold
5.1.1.7
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008837Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. +14 total
0.401 No Hit N/A —
4922 PA4996 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase PA4996, hldE, rfaE AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0033785Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP. +912 total
0.401 Hit 53.8% 1.60e-06
4923 PA0700 hypothetical protein PA0700 AlphaFold – – 0.401 No Hit N/A —
4924 PA2164 glycosyl hydrolase PA2164 AlphaFold
3.2.1.141
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033942Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan. GO:0005992The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide that consists of two molecules of glucose and is isomeric with sucrose. +25 total
0.4 Hit 27.3% 1.97e-17
4925 PA0932 cysteine synthase B PA0932, cysM AlphaFold
2.5.1.47
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004124Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. GO:0019344The chemical reactions and pathways resulting in the formation of L-cysteine, 2-amino-3-mercaptopropanoic acid. +14 total
0.4 Hit 48.0% 8.05e-23
Page of 223 · 5572 total proteins