Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5076 PA1198 hypothetical protein PA1198 AlphaFold –
GO:0008234Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. GO:0004175Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. GO:0000270The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. +14 total
0.343 No Hit N/A —
5077 PA0903 alanine--tRNA ligase alaS, PA0903 AlphaFold
6.1.1.7
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004813Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. +912 total
0.343 Hit 56.8% 8.25e-11
5078 PA0402 aspartate carbamoyltransferase pyrB, PA0402 AlphaFold
2.1.3.2
GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. GO:0004070Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H+ + phosphate. GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. +36 total
0.342 Hit 32.2% 1.82e-38
5079 PA2721 hypothetical protein PA2721 Experimental + AlphaFold – – 0.341 No Hit N/A —
5080 PA1937 hypothetical protein PA1937 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
0.341 No Hit N/A —
5081 PA1043 hypothetical protein PA1043 AlphaFold – – 0.341 Hit 32.0% 6.96e-06
5082 PA1756 phosphoadenosine phosphosulfate reductase PA1756, cysH Experimental + AlphaFold
1.8.4.10
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0043866Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin. +710 total
0.34 No Hit N/A —
5083 PA1552.1 cytochrome C oxidase cbb3-type subunit CcoQ ccoQ1 AlphaFold –
GO:0004129Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out).
0.339 No Hit N/A —
5084 PA0562 hydrolase PA0562 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
0.339 Hit 30.4% 1.87e-13
5085 PA4898 vanillate porin OpdK PA4898, opdK Experimental + AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.338 No Hit N/A —
5086 PA4529 dephospho-CoA kinase coaE, PA4529 AlphaFold
2.7.1.24
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004140Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+. +14 total
0.338 Hit 43.8% 9.97e-22
5087 PA1364 transmembrane sensor PA1364 AlphaFold –
GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.
0.338 No Hit N/A —
5088 PA5460 hypothetical protein PA5460 AlphaFold – – 0.337 No Hit N/A —
5089 PA3181 2-dehydro-3-deoxy-phosphogluconate aldolase eda, PA3181 AlphaFold
4.1.2.14
GO:0106009Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. Specific for the (4S) enantiomer of 4-hydroxy-2-oxoglutarate. GO:0008675Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. +25 total
0.337 No Hit N/A —
5090 PA2140 metallothionein PA2140 AlphaFold –
GO:0046872Binding to a metal ion.
0.337 No Hit N/A —
5091 PA0712 hypothetical protein PA0712 AlphaFold – – 0.336 No Hit N/A —
5092 PA4854 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase PA4854, purH AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003937Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. GO:0004643Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. +36 total
0.335 Hit 58.7% 2.39e-23
5093 PA4021 transcriptional regulator PA4021 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +710 total
0.335 No Hit N/A —
5094 PA2747a hypothetical protein ColabFold – – 0.335 No Hit N/A —
5095 PA1974 hypothetical protein PA1974 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.335 No Hit N/A —
5096 PA1256 amino acid ABC transporter ATP binding protein PA1256 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015424Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.335 Hit 35.9% 6.60e-30
5097 PA3416 pyruvate dehydrogenase E1 component subunit beta PA3416 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0009083The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. GO:0007584Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. +14 total
0.333 Hit 40.1% 2.99e-85
5098 PA1468 hypothetical protein PA1468 AlphaFold – – 0.333 No Hit N/A —
5099 PA0530 class III pyridoxal phosphate-dependent aminotransferase PA0530 AlphaFold –
GO:0042802Binding to an identical protein or proteins. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +14 total
0.333 Hit 30.2% 3.67e-46
5100 PA1228 hypothetical protein PA1228 AlphaFold – – 0.332 No Hit N/A —
Page of 223 · 5572 total proteins