Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5051 PA2780 hypothetical protein PA2780 Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +58 total
0.355 No Hit N/A —
5052 PA2342 mannitol dehydrogenase PA2342, mtlD AlphaFold –
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0019594The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
0.355 No Hit N/A —
5053 PA5340 hypothetical protein PA5340 AlphaFold – – 0.354 No Hit N/A —
5054 PA4851 hypothetical protein PA4851 AlphaFold – – 0.354 No Hit N/A —
5055 PA3919 hypothetical protein PA3919 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
0.354 No Hit N/A —
5056 PA5391 hypothetical protein PA5391 AlphaFold – – 0.353 No Hit N/A —
5057 PA0373 signal recognition particle receptor FtsY PA0373, ftsY AlphaFold
3.6.5.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005525Binding to GTP, guanosine triphosphate. +58 total
0.353 Hit 37.5% 1.74e-31
5058 PA3392 nitrous-oxide reductase nosZ, PA3392 AlphaFold
1.7.2.4
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0005509Binding to a calcium ion (Ca2+). +58 total
0.351 No Hit N/A —
5059 PA1955 hypothetical protein PA1955, fapB AlphaFold –
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:1990000The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. +14 total
0.351 No Hit N/A —
5060 PA1294 ribonuclease D rnd, PA1294 AlphaFold
3.1.13.5
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0003676Binding to a nucleic acid. +710 total
0.35 Hit 27.7% 7.24e-18
5061 PA2642 NADH-quinone oxidoreductase subunit G nuoG, PA2642 AlphaFold
7.1.1.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +811 total
0.349 Hit 41.7% 1.92e-07
5062 PA1421 guanidinobutyrase gbuA, PA1421 Experimental + AlphaFold
3.5.3.7
GO:0008783Catalysis of the reaction: agmatine + H2O = putrescine + urea. GO:0047971Catalysis of the reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea. GO:0046872Binding to a metal ion. +36 total
0.349 Hit 61.4% 5.58e-141
5063 PA3202 hypothetical protein PA3202 AlphaFold – – 0.348 No Hit N/A —
5064 PA1744 hypothetical protein PA1744 AlphaFold – – 0.348 No Hit N/A —
5065 PA0756 two-component response regulator PA0756 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +47 total
0.348 No Hit N/A —
5066 PA1026 hypothetical protein PA1026 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0032784Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.
0.347 No Hit N/A —
5067 PA0011 lipid A biosynthesis lauroyl acyltransferase PA0011 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +710 total
0.347 No Hit N/A —
5068 PA5164 dTDP-4-dehydrorhamnose 3,5-epimerase rmlC, PA5164 Experimental + AlphaFold
5.1.3.13
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008830Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose. GO:0019305The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate. +36 total
0.346 No Hit N/A —
5069 PA2772a hypothetical protein ColabFold – – 0.346 No Hit N/A —
5070 PA3101 type II secretion system protein G xcpT, PA3101, pddA AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
0.345 No Hit N/A —
5071 PA1563 23S rRNA (cytidine(2498)-2'-O)-methyltransferase RlmM rlmM, PA1563 AlphaFold
2.1.1.186
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0070677Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +25 total
0.345 No Hit N/A —
5072 PA2747 hypothetical protein PA2747 AlphaFold – – 0.344 No Hit N/A —
5073 PA2051 transmembrane sensor PA2051 AlphaFold – – 0.344 No Hit N/A —
5074 PA1521 guanine deaminase PA1521 AlphaFold
3.5.4.3
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008892Catalysis of the reaction: guanine + H2O + H+ = xanthine + NH4+. GO:0008270Binding to a zinc ion (Zn). +47 total
0.344 Hit 37.8% 1.36e-20
5075 PA4402 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase argJ, PA4402 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004042Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H+. GO:0004358Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine. +25 total
0.343 No Hit N/A —
Page of 223 · 5572 total proteins