Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5126 PA3129 tRNA-dihydrouridine synthase C PA3129, dusC AlphaFold
1.3.1.-
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0000049Binding to a transfer RNA. +47 total
0.32 Hit 33.9% 6.24e-10
5127 PA1986 coenzyme PQQ synthesis protein B PA1986, pqqB AlphaFold –
GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.
0.32 No Hit N/A —
5128 PA1768 hypothetical protein PA1768 Experimental + AlphaFold – – 0.32 No Hit N/A —
5129 PA0667 hypothetical protein PA0667 AlphaFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0046872Binding to a metal ion. GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +25 total
0.32 No Hit N/A —
5130 PA3165 histidinol-phosphate aminotransferase PA3165, hisC2 AlphaFold
2.6.1.9
GO:0004400Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. +36 total
0.319 Hit 25.5% 1.38e-09
5131 PA1550 hypothetical protein PA1550 AlphaFold – – 0.318 No Hit N/A —
5132 PA4862 ABC transporter ATP-binding protein PA4862 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015803The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
0.317 Hit 34.6% 8.03e-13
5133 PA3007 LexA repressor lexA, PA3007 Experimental + AlphaFold
3.4.21.88
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +811 total
0.317 No Hit N/A —
5134 PA0785 FMN-dependent NADH-azoreductase AzoR PA0785, azoR1 Experimental + AlphaFold
1.6.5.- 1.7.1.17
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016652Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. +36 total
0.316 Hit 37.8% 9.18e-08
5135 PA3915 molybdopterin biosynthesis protein B PA3915, moaB1 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005525Binding to GTP, guanosine triphosphate. GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
0.315 Hit 33.3% 5.37e-07
5136 PA1987 pyrroloquinoline-quinone synthase pqqC, PA1987 AlphaFold
1.3.3.11
GO:0033732Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 2 H2O + 2 H2O2 + H+ + pyrroloquinoline quinone. GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed.
0.315 No Hit N/A —
5137 PA0584 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase PA0584, cca AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004810Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate. GO:0160016Catalysis of the reaction: a tRNA with a 3' CCA end + 2 CTP + ATP = a tRNA with a 3' CCACCA end + 3 diphosphate. +1013 total
0.314 Hit 33.3% 1.77e-08
5138 PA2126 hypothetical protein PA2126 AlphaFold –
GO:0071453Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
0.313 No Hit N/A —
5139 PA1784 hypothetical protein PA1784 AlphaFold – – 0.313 No Hit N/A —
5140 PA1078 flagellar basal body rod protein FlgC flgC, PA1078 AlphaFold –
GO:0009288A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0030694The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings. GO:0071978Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. +14 total
0.313 No Hit N/A —
5141 PA0931 outer membrane receptor FepA PA0931, pirA Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0046930A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. GO:0042931Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other. +811 total
0.313 No Hit N/A —
5142 PA0617 bacteriophage protein WR2, PA0617 AlphaFold – – 0.313 No Hit N/A —
5143 PA3525 argininosuccinate synthase PA3525, argG AlphaFold
6.3.4.5
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004055Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.312 Hit 53.0% 7.10e-65
5144 PA5143 imidazoleglycerol-phosphate dehydratase PA5143, hisB AlphaFold
4.2.1.19
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004424Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. GO:0000105The chemical reactions and pathways resulting in the formation of L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
0.311 No Hit N/A —
5145 PA3402 hypothetical protein PA3402 AlphaFold – – 0.311 No Hit N/A —
5146 PA5438 transcriptional regulator PA5438 Experimental + AlphaFold –
GO:0097367Binding to a carbohydrate derivative. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
0.31 No Hit N/A —
5147 PA5285 hypothetical protein PA5285 AlphaFold – – 0.31 No Hit N/A —
5148 PA2023 UTP-glucose-1-phosphate uridylyltransferase PA2023, galU Experimental + AlphaFold
2.7.7.9
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003983Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. GO:0009244The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. +25 total
0.308 Hit 26.5% 7.88e-10
5149 PA1090 hypothetical protein PA1090 AlphaFold –
GO:0061602Catalysis of the reaction: Mo-molybdopterin + CTP + H+ = Mo-molybdopterin cytosine dinucleotide + diphosphate. GO:1902760The chemical reactions and pathways resulting in the formation of Mo(VI)-molybdopterin cytosine dinucleotide.
0.308 No Hit N/A —
5150 PA5040 type 4 fimbrial biogenesis outer membrane protein PilQ PA5040, pilQ AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0009306The controlled release of proteins from a cell. GO:0043683The assembly from its constituent parts of a type IV pilus. +14 total
0.307 No Hit N/A —
Page of 223 · 5572 total proteins