Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5026 PA2927 hypothetical protein PA2927 AlphaFold – – 0.362 No Hit N/A —
5027 PA3954 hypothetical protein PA3954 AlphaFold –
GO:0008726Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN. GO:0046306The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group. GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.
0.361 No Hit N/A —
5028 PA1555.1 cytochrome C oxidase cbb3-type subunit CcoQ ccoQ2 AlphaFold –
GO:0004129Catalysis of the reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out).
0.361 No Hit N/A —
5029 PA5119 glutamine synthetase glnA, PA5119 AlphaFold
6.3.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +69 total
0.36 Hit 25.9% 1.06e-15
5030 PA4179 porin PA4179 Experimental + AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0.36 No Hit N/A —
5031 PA3273 hypothetical protein ColabFold – – 0.36 No Hit N/A —
5032 PA2895 hypothetical protein PA2895 AlphaFold –
GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. GO:2000143Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation.
0.36 No Hit N/A —
5033 PA2551 transcriptional regulator PA2551 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.36 No Hit N/A —
5034 PA1268 4-hydroxyproline 2-epimerase PA1268 Experimental + AlphaFold
5.1.1.8
GO:0047580Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline.
0.36 Hit 30.7% 2.29e-33
5035 PA4764 ferric uptake regulation protein fur, PA4764 Experimental + AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +811 total
0.359 No Hit N/A —
5036 PA3889 ABC transporter PA3889 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0015226Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. +58 total
0.359 No Hit N/A —
5037 PA3784 hypothetical protein PA3784 AlphaFold – – 0.359 No Hit N/A —
5038 PA2816 hypothetical protein PA2816 AlphaFold – – 0.358 No Hit N/A —
5039 PA1375 erythronate-4-phosphate dehydrogenase PA1375, pdxB Experimental + AlphaFold
1.1.1.290
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033711Catalysis of the reaction: 4-phospho-D-erythronate + NAD+ = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H+ + NADH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +58 total
0.358 Hit 34.1% 1.55e-12
5040 PA5013 branched-chain amino acid aminotransferase PA5013, ilvE Experimental + AlphaFold
2.6.1.42
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004084Catalysis of the reaction: a branched-chain amino acid (L-leucine, L-isoleucine and L-valine) + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. GO:0052656Catalysis of the reaction: L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate. +811 total
0.357 Hit 26.0% 5.64e-12
5041 PA3440a type III effector protein ColabFold – – 0.357 No Hit N/A —
5042 PA2183 hypothetical protein PA2183 AlphaFold – – 0.357 No Hit N/A —
5043 PA0622 bacteriophage protein FIR2, PA0622 AlphaFold – – 0.357 No Hit N/A —
5044 PA0615 hypothetical protein PA0615 AlphaFold – – 0.357 No Hit N/A —
5045 PA3656 30S ribosomal protein S2 PA3656, rpsB AlphaFold –
GO:0022627The small subunit of a ribosome located in the cytosol. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +25 total
0.356 Hit 29.6% 1.70e-22
5046 PA2822 hypothetical protein PA2822 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033745Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol. GO:0005515Binding to a protein.
0.356 No Hit N/A —
5047 PA2156 hypothetical protein PA2156 AlphaFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.356 No Hit N/A —
5048 PA0598 hypothetical protein PA0598 AlphaFold – – 0.356 No Hit N/A —
5049 PA4858 hypothetical protein PA4858 AlphaFold –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.355 No Hit N/A —
5050 PA3602 hypothetical protein PA3602 AlphaFold –
GO:0015930Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. GO:0019676The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen. GO:0006537OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. +14 total
0.355 No Hit N/A —
Page of 223 · 5572 total proteins