Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5101 PA5404 hypothetical protein PA5404 AlphaFold – – 0.331 No Hit N/A —
5102 PA4905 vanillate O-demethylase PA4905, vanB AlphaFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.331 No Hit N/A —
5103 PA4084 usher CupB3 PA4084, cupB3 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. +25 total
0.331 No Hit N/A —
5104 PA4056 riboflavin-specific deaminase/reductase ribD, PA4056 AlphaFold –
GO:0008703Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + H+ + NADPH. GO:0008835Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O + H+ = 5-amino-6-(5-phosphoribosylamino)uracil + NH4. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +47 total
0.331 No Hit N/A —
5105 PA3948 two-component response regulator RocA1 PA3948, rocA1 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +36 total
0.331 No Hit N/A —
5106 PA0457 hypothetical protein PA0457 AlphaFold – – 0.331 No Hit N/A —
5107 PA0432 adenosylhomocysteinase ahcY, PA0432, sahH Experimental + AlphaFold
3.13.2.1
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004013Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. GO:0071269The chemical reactions and pathways resulting in the formation of L-homocysteine. +25 total
0.331 Hit 60.2% 2.84e-38
5108 PA0173 chemotaxis response regulator protein-glutamate methylesterase PA0173, cheB2 AlphaFold
3.1.1.61 3.5.1.44
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. GO:0008984Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. +47 total
0.331 No Hit N/A —
5109 PA3200 hypothetical protein PA3200 AlphaFold –
GO:0035312Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. GO:0004534Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.33 No Hit N/A —
5110 PA2812 ABC transporter ATP-binding protein PA2812 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +14 total
0.33 Hit 38.3% 2.54e-34
5111 PA5385 carnitine dehydrogenase cdhB, PA5385 AlphaFold
3.1.2.33
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+. GO:0042413The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
0.328 No Hit N/A —
5112 PA5379 L-serine dehydratase PA5379, sdaB AlphaFold
4.3.1.17
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0031459Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in). GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. +36 total
0.328 No Hit N/A —
5113 PA3107 O-succinylhomoserine sulfhydrylase metZ, PA3107 AlphaFold
2.5.1.-
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016846Catalysis of the elimination of hydrogen sulfide or substituted H2S. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +69 total
0.327 Hit 36.1% 9.76e-75
5114 PA3601 50S ribosomal protein L31 type B rpmE2, PA3601 AlphaFold –
GO:1990904A macromolecular complex that contains both RNA and protein molecules. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +14 total
0.326 No Hit N/A —
5115 PA1641 hypothetical protein PA1641 AlphaFold – – 0.326 No Hit N/A —
5116 PA4250 30S ribosomal protein S14 rpsN, PA4250 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0015935The smaller of the two subunits of a ribosome. GO:0019843Binding to a ribosomal RNA. +36 total
0.325 Hit 32.3% 1.62e-09
5117 PA2783 hypothetical protein mep72, PA2783 AlphaFold
3.4.24.33
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. +58 total
0.325 No Hit N/A —
5118 PA2570 PA-I galactophilic lectin pa1L, PA2570, lecA Experimental + AlphaFold –
GO:0009986The external part of the cell wall and/or plasma membrane. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +25 total
0.324 No Hit N/A —
5119 PA5028 hypothetical protein PA5028 AlphaFold – – 0.322 No Hit N/A —
5120 PA2471 hypothetical protein PA2471 Experimental + AlphaFold –
GO:0018773Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate. GO:0046872Binding to a metal ion. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.322 Hit 37.2% 3.50e-43
5121 PA1524 xanthine dehydrogenase PA1524, xdhA AlphaFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0005506Binding to an iron (Fe) ion. +58 total
0.322 Hit 47.1% 6.43e-27
5122 PA1837 hypothetical protein PA1837 AlphaFold – – 0.321 No Hit N/A —
5123 PA1749 hypothetical protein PA1749 AlphaFold – – 0.321 Hit 34.1% 9.01e-09
5124 PA4743 ribosome-binding factor A rbfA, PA4743 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043024Binding to a small ribosomal subunit. GO:0030490Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. +25 total
0.32 No Hit N/A —
5125 PA3175 formimidoylglutamase PA3175 AlphaFold
3.5.3.8
GO:0008783Catalysis of the reaction: agmatine + H2O = putrescine + urea. GO:0050415Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide. GO:0030145Binding to a manganese ion (Mn). +58 total
0.32 Hit 25.7% 9.04e-09
Page of 223 · 5572 total proteins