Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
526 PA2384 hypothetical protein PA2384 AlphaFold – – 0.921 No Hit N/A —
527 PA1878 hypothetical protein PA1878 AlphaFold –
GO:0002953Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate. GO:0046872Binding to a metal ion.
0.921 Hit 37.0% 6.77e-12
528 PA0947 DNA replication initiation factor PA0947 AlphaFold –
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0006270The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding. GO:0032297Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.
0.921 No Hit N/A —
529 PA0908 hypothetical protein PA0908 AlphaFold –
GO:0001896A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation. GO:0071236Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
0.921 No Hit N/A —
530 PA5467 hypothetical protein PA5467 AlphaFold – – 0.92 No Hit N/A —
531 PA5135 hypothetical protein PA5135 AlphaFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.92 No Hit N/A —
532 PA5079 D-tyrosyl-tRNA(Tyr) deacylase dtd, PA5079 AlphaFold
3.1.1.96
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051500Catalysis of the reaction: D-tyrosyl-tRNATyr + H2O = D-tyrosine + tRNATyr. Removal of a D-tyrosine from a charged tRNA(Tyr). GO:0106026Catalysis of the reaction: glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H+. +69 total
0.92 Hit 45.3% 2.94e-34
533 PA5048 nuclease PA5048 AlphaFold –
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.92 No Hit N/A —
534 PA4600 transcriptional regulator NfxB nfxB, PA4600 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0001217A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. +36 total
0.92 No Hit N/A —
535 PA4355 major facilitator superfamily transporter PA4355 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.92 No Hit N/A —
536 PA2708 hypothetical protein PA2708 AlphaFold – – 0.92 No Hit N/A —
537 PA2000 dehydrocarnitine CoA transferase subunit B PA2000, dhcB AlphaFold
2.8.3.6
GO:0047569Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA. GO:0042952A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. GO:0042413The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. +14 total
0.92 Hit 50.2% 2.86e-69
538 PA1640 hypothetical protein PA1640 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
0.92 Hit 33.9% 4.35e-24
539 PA1066 short-chain dehydrogenase PA1066 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.92 No Hit N/A —
540 PA5032 transcriptional regulator PA5032 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.919 No Hit N/A —
541 PA4871 hypothetical protein PA4871 AlphaFold – – 0.919 No Hit N/A —
542 PA1938 hypothetical protein PA1938 AlphaFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.919 No Hit N/A —
543 PA1282 major facilitator superfamily transporter PA1282 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +14 total
0.919 Hit 31.3% 1.93e-06
544 PA0870 aromatic amino acid aminotransferase PA0870, phhC AlphaFold
2.6.1.57
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042802Binding to an identical protein or proteins. GO:0004069Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. +811 total
0.919 Hit 40.4% 1.49e-92
545 PA0845 neutral ceramidase PA0845 Experimental + AlphaFold
3.5.1.23
GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872Binding to a metal ion. +58 total
0.919 Hit 36.1% 3.16e-129
546 PA0438 cytosine permease PA0438, codB AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015209Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other. GO:0019858The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives. +36 total
0.919 No Hit N/A —
547 PA0388 hypothetical protein PA0388 Experimental + AlphaFold – – 0.919 No Hit N/A —
548 PA5252a hypothetical protein ColabFold – – 0.918 No Hit N/A —
549 PA5146 hypothetical protein PA5146 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0090313Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
0.918 No Hit N/A —
550 PA4411 UDP-N-acetylmuramate--L-alanine ligase murC, PA4411 Experimental + AlphaFold
6.3.2.8
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008763Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H+ + phosphate + UDP-N-acetylmuramoyl-L-alanine. +69 total
0.918 No Hit N/A —
Page of 223 · 5572 total proteins