Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
576 PA3592 hypothetical protein PA3592 AlphaFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.916 Hit 36.6% 5.60e-72
577 PA3586 hydrolase PA3586 AlphaFold –
GO:0004806Catalysis of the reaction: a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+. GO:0046503The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone.
0.916 Hit 26.0% 3.31e-09
578 PA3130 hypothetical protein PA3130 AlphaFold –
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
0.916 No Hit N/A —
579 PA3074 hypothetical protein PA3074 AlphaFold –
GO:0005515Binding to a protein.
0.916 No Hit N/A —
580 PA2924 histidine ABC transporter permease HisQ PA2924, hisQ AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +47 total
0.916 No Hit N/A —
581 PA2593 quorum threshold expression protein QteE qteE, PA2593 AlphaFold – – 0.916 No Hit N/A —
582 PA2159 hypothetical protein PA2159 AlphaFold – – 0.916 No Hit N/A —
583 PA1652 hypothetical protein PA1652 AlphaFold – – 0.916 No Hit N/A —
584 PA1316 major facilitator superfamily transporter PA1316 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.916 Hit 26.4% 4.59e-06
585 PA0605 ABC transporter permease PA0605 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015417Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in). GO:1903711The process in which spermidine is transported across a membrane. +25 total
0.916 No Hit N/A —
586 PA5103 hypothetical protein PA5103 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.915 No Hit N/A —
587 PA4273 50S ribosomal protein L1 PA4273, rplA AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0019843Binding to a ribosomal RNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +58 total
0.915 No Hit N/A —
588 PA3936 taurine ABC transporter permease PA3936 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042918The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical. GO:0010438Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur. +25 total
0.915 No Hit N/A —
589 PA3468 hypothetical protein PA3468 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. GO:0071470Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. +25 total
0.915 No Hit N/A —
590 PA3415 branched-chain alpha-keto acid dehydrogenase subunit E2 PA3415 AlphaFold
2.3.1.-
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
0.915 Hit 35.6% 3.36e-20
591 PA3270 hypothetical protein PA3270 Experimental + AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.915 No Hit N/A —
592 PA1055 monovalent cation/H+ antiporter subunit C PA1055 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015385Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). GO:0035725A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
0.915 No Hit N/A —
593 PA0911 hypothetical protein PA0911 AlphaFold –
GO:0001896A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation. GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
0.915 No Hit N/A —
594 PA0679 hypothetical protein PA0679 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.915 No Hit N/A —
595 PA0276 hypothetical protein PA0276 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046521The chemical reactions and pathways resulting in the breakdown of sphingoids, any of a class of compounds comprising sphinganine and its homologues and stereoisomers, and derivatives of these compounds.
0.915 No Hit N/A —
596 PA0230 3-carboxy-cis,cis-muconate cycloisomerase PA0230, pcaB AlphaFold
5.5.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0047472Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. +36 total
0.915 Hit 31.4% 1.12e-07
597 PA0144 hypothetical protein PA0144 AlphaFold –
GO:0070694Catalysis of the reaction: 5-hydroxymethyl-dUMP + H2O = 2-deoxy-D-ribose 5-phosphate + 5-hydroxymethyluracil. GO:0009159The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.
0.915 No Hit N/A —
598 PA0086 hypothetical protein PA0086, tagJ Experimental + AlphaFold –
GO:0005515Binding to a protein.
0.915 No Hit N/A —
599 PA4887 major facilitator superfamily transporter PA4887 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.914 No Hit N/A —
600 PA4415 phospho-N-acetylmuramoyl-pentapeptide- transferase mraY, PA4415 AlphaFold
2.7.8.13
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. GO:0008963Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine = Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UMP. +811 total
0.914 No Hit N/A —
Page of 223 · 5572 total proteins