Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1276 PA2863 lipase chaperone PA2863, lifO, lipH, lipB AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051082Binding to an unfolded protein. GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. +25 total
0.86 No Hit N/A —
1277 PA2645 NADH-quinone oxidoreductase subunit J nuoJ, PA2645 AlphaFold
7.1.1.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045271Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). +14 total
0.86 No Hit N/A —
1278 PA2536 phosphatidate cytidylyltransferase PA2536 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0009273The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli.
0.86 Hit 25.1% 2.02e-06
1279 PA2391 hypothetical protein PA2391, opmQ AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:1990281A protein complex that is capable of efflux transmembrane transporter activity. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
0.86 No Hit N/A —
1280 PA1683 methylthioribulose-1-phosphate dehydratase mtnB, PA1683 AlphaFold
4.2.1.109
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046570Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H2O. GO:0008270Binding to a zinc ion (Zn). +36 total
0.86 Hit 28.5% 5.06e-12
1281 PA1591 hypothetical protein PA1591 AlphaFold – – 0.86 No Hit N/A —
1282 PA1430 transcriptional regulator LasR lasR, PA1430 Experimental + AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +811 total
0.86 No Hit N/A —
1283 PA1140 hypothetical protein PA1140 Experimental + AlphaFold –
GO:0071522Catalysis of the reaction: (S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4+. GO:0006145The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0010136The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium.
0.86 No Hit N/A —
1284 PA0742 hypothetical protein ColabFold – – 0.86 No Hit N/A —
1285 PA5377 ABC transporter permease PA5377 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:1902495A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. GO:0005275Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. +1013 total
0.859 No Hit N/A —
1286 PA5120 hypothetical protein PA5120 AlphaFold – – 0.859 No Hit N/A —
1287 PA5074 ABC transporter ATP-binding protein PA5074 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015424Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.859 Hit 63.9% 7.15e-08
1288 PA4900 major facilitator superfamily transporter PA4900 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.859 Hit 27.7% 1.17e-07
1289 PA4313 hypothetical protein PA4313 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.859 No Hit N/A —
1290 PA3738 site-specific tyrosine recombinase XerD PA3738, xerD AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0048476An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
0.859 No Hit N/A —
1291 PA3250 hypothetical protein PA3250 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030975Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. +14 total
0.859 No Hit N/A —
1292 PA2918 short-chain dehydrogenase PA2918 AlphaFold –
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
0.859 Hit 27.2% 5.32e-10
1293 PA2664 flavohemoprotein fhp, PA2664, hmp AlphaFold
1.14.12.17
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. +912 total
0.859 Hit 25.2% 8.82e-08
1294 PA1587 2-oxoglutarate dehydrogenase complex dihydrolipoyl dehydrogenase PA1587, lpdG Experimental + AlphaFold
1.8.1.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004148Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +58 total
0.859 Hit 65.8% 3.12e-23
1295 PA1579 hypothetical protein PA1579 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008289Binding to a lipid.
0.859 Hit 26.1% 8.63e-06
1296 PA1434 hypothetical protein PA1434 AlphaFold – – 0.859 No Hit N/A —
1297 PA1380 transcriptional regulator PA1380 AlphaFold –
GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.859 No Hit N/A —
1298 PA1335 two-component response regulator PA1335 AlphaFold –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +710 total
0.859 No Hit N/A —
1299 PA1328 transcriptional regulator PA1328 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.859 No Hit N/A —
1300 PA1040 hypothetical protein PA1040 AlphaFold – – 0.859 No Hit N/A —
Page of 223 · 5572 total proteins