Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1326 PA2902 hypothetical protein PA2902 AlphaFold – – 0.857 No Hit N/A —
1327 PA2873 protein-glutamine gamma-glutamyltransferase tgpA, PA2873 Experimental + AlphaFold
2.3.2.13
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003810Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
0.857 No Hit N/A —
1328 PA2768 hypothetical protein PA2768 AlphaFold – – 0.857 No Hit N/A —
1329 PA2669 hypothetical protein PA2669 AlphaFold – – 0.857 No Hit N/A —
1330 PA2308 ABC transporter ATP-binding protein PA2308 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.857 Hit 33.5% 1.04e-14
1331 PA2269 hypothetical protein PA2269 AlphaFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.857 No Hit N/A —
1332 PA2014 methylcrotonyl-CoA carboxylase subunit beta liuB, PA2014 Experimental + AlphaFold –
GO:1905202A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA. GO:0004485Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate. GO:0008300The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. +25 total
0.857 Hit 68.5% 0.00e+00
1333 PA1902 phenazine biosynthesis protein PhzD PA1902, phzD, phzD2 Experimental + AlphaFold
3.3.2.15
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008908Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate. GO:0002047The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.
0.857 No Hit N/A —
1334 PA1822 hypothetical protein fimL, PA1822 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +14 total
0.857 No Hit N/A —
1335 PA0915 hypothetical protein PA0915 AlphaFold – – 0.857 No Hit N/A —
1336 PA0707 transcriptional regulator ToxR regA, toxR, PA0707 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
0.857 No Hit N/A —
1337 PA0676 sigma factor regulator VreR PA0676, vreR, pigE AlphaFold –
GO:0016989The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.
0.857 No Hit N/A —
1338 PA0653 hypothetical protein PA0653 AlphaFold – – 0.857 No Hit N/A —
1339 PA0155 transcriptional regulator PcaR pcaR, PA0155 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0046278The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid). +36 total
0.857 No Hit N/A —
1340 PA5486 hypothetical protein PA5486 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.856 No Hit N/A —
1341 PA4892 urease accessory protein UreF PA4892, ureF AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016151Binding to a nickel (Ni) cation. GO:0018237Increases the activity of urease by promoting the incorporation of nickel into the active site. +25 total
0.856 No Hit N/A —
1342 PA4395 nucleotide-binding protein PA4395 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.856 No Hit N/A —
1343 PA4387 phage exclusion suppressor FxsA PA4387 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.856 No Hit N/A —
1344 PA3564 hypothetical protein PA3564 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0046872Binding to a metal ion.
0.856 Hit 33.1% 2.02e-10
1345 PA2675 type II secretion system protein PA2675 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
0.856 No Hit N/A —
1346 PA2559a hypothetical protein srfA Experimental + AlphaFold – – 0.856 No Hit N/A —
1347 PA2491 oxidoreductase PA2491 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050709Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. GO:1900377Any process that stops, prevents or reduces the frequency, rate or extent of secondary metabolite biosynthetic process. +14 total
0.856 Hit 37.5% 7.40e-06
1348 PA2219 transcriptional regulator OpdE opdE, PA2219 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.856 No Hit N/A —
1349 PA1194 amino acid permease PA1194 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043858Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out). GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +36 total
0.856 No Hit N/A —
1350 PA1136 transcriptional regulator PA1136 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.856 No Hit N/A —
Page of 223 · 5572 total proteins