Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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701 / 5572 proteins Structure: Experimental

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
126 PA2302 protein AmbE ambE, PA2302 Experimental + AlphaFold DB model
6.2.1.68
GO:0016405Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. GO:0031177Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. +36 total
No map 0.871 Hit 46.4% 1.76e-07
127 PA5185 hypothetical protein PA5185 Experimental + AlphaFold DB model –
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
No map 0.87 No Hit N/A —
128 PA3743 tRNA (guanine-N(1)-)-methyltransferase trmD, PA3743 Experimental + AlphaFold DB model
2.1.1.228
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0052906Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. GO:0002939The process whereby a guanine in tRNA is methylated at position N1 of the guanine. +14 total
No map 0.869 No Hit N/A —
129 PA3363 aliphatic amidase regulator amiR, PA3363 Experimental + AlphaFold DB model –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. GO:0034251OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of amides. +14 total
No map 0.869 No Hit N/A —
130 PA4984 transcriptional regulator PA4984 Experimental + AlphaFold DB model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.868 No Hit N/A —
131 PA4827 arylamine N-acetyltransferase PA4827 Experimental + AlphaFold DB model –
GO:0004060Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule.
No map 0.867 Hit 26.5% 3.41e-17
132 PA4109 transcriptional regulator AmpR PA4109, ampR Experimental + AlphaFold DB model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +710 total
No map 0.867 No Hit N/A —
133 PA1724 type III export protein PscK PA1724, pscK Experimental + AlphaFold DB model –
GO:0030254The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.
No map 0.867 No Hit N/A —
134 PA2629 adenylosuccinate lyase purB, PA2629 Experimental + AlphaFold DB model
4.3.2.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0070626Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. GO:0004018Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. +69 total
No map 0.865 Hit 24.5% 7.34e-06
135 PA2588 transcriptional regulator PA2588 Experimental + AlphaFold DB model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.865 No Hit N/A —
136 PA1430 transcriptional regulator LasR PA1430, lasR Experimental + AlphaFold DB model –
GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0001216A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +811 total
No map 0.86 No Hit N/A —
137 PA1140 hypothetical protein PA1140 Experimental + AlphaFold DB model –
GO:0071522Catalysis of the reaction: (S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH4+. GO:0006145The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0010136The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium.
No map 0.86 No Hit N/A —
138 PA1587 2-oxoglutarate dehydrogenase complex dihydrolipoyl dehydrogenase PA1587, lpdG Experimental + AlphaFold DB model
1.8.1.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004148Catalysis of the reaction: N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +58 total
No map 0.859 Hit 65.8% 3.12e-23
139 PA0904 aspartokinase lysC, PA0904 Experimental + AlphaFold DB model
2.7.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004072Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +58 total
No map 0.859 No Hit N/A —
140 PA3685 hypothetical protein PA3685 Experimental + AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base).
No map 0.858 No Hit N/A —
141 PA0506 acyl-CoA dehydrogenase PA0506 Experimental + AlphaFold DB model
1.3.99.41
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
No map 0.858 Hit 36.2% 8.25e-07
142 PA4202 hypothetical protein nmoA, PA4202 Experimental + AlphaFold DB model
1.13.12.-
GO:0018580Catalysis of the reaction: ethylnitronate + O2 = acetaldehyde + nitrite. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. GO:0009636Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
No map 0.857 No Hit N/A —
143 PA2873 protein-glutamine gamma-glutamyltransferase PA2873, tgpA Experimental + AlphaFold DB model
2.3.2.13
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003810Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.
No map 0.857 No Hit N/A —
144 PA2014 methylcrotonyl-CoA carboxylase subunit beta PA2014, liuB Experimental + AlphaFold DB model –
GO:1905202A protein complex capable of methylcrotonoyl-CoA carboxylase activity. In mammals, it is a mitochondrial complex comprising a dodecamer of 6 alpha and 6 beta subunits: MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation; MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA. GO:0004485Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H+ + phosphate. GO:0008300The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. +25 total
No map 0.857 Hit 68.5% 0.00e+00
145 PA1902 phenazine biosynthesis protein PhzD PA1902, phzD, phzD2 Experimental + AlphaFold DB model
3.3.2.15
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008908Catalysis of the reaction: H2O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate. GO:0002047The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.
No map 0.857 No Hit N/A —
146 PA2559a hypothetical protein srfA Experimental + AlphaFold DB model – – No map 0.856 No Hit N/A —
147 PA4000 hypothetical protein rlpA, PA4000 Experimental + AlphaFold DB model
4.2.2.-
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008932Catalysis of the endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. +47 total
No map 0.854 No Hit N/A —
148 PA0172 hypothetical protein PA0172 Experimental + AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0046872Binding to a metal ion. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. +14 total
No map 0.852 No Hit N/A —
149 PA2940 acyl-CoA thiolase PA2940 Experimental + AlphaFold DB model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033812Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. +47 total
No map 0.851 Hit 39.3% 3.44e-34
150 PA0508 acyl-CoA dehydrogenase PA0508 Experimental + AlphaFold DB model
1.3.99.41
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
No map 0.85 Hit 34.0% 1.34e-06
Page of 29 · 701 total proteins