Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2126 PA1092 B-type flagellin PA1092, fliC Experimental + AlphaFold –
GO:0009288A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0005198The action of a molecule that contributes to the structural integrity of a complex. +14 total
0.789 No Hit N/A —
2127 PA0968 hypothetical protein PA0968 Experimental + AlphaFold –
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.
0.789 No Hit N/A —
2128 PA0847 hypothetical protein PA0847 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0061939Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal. +36 total
0.789 No Hit N/A —
2129 PA0814 hypothetical protein PA0814 Experimental + AlphaFold – – 0.789 No Hit N/A —
2130 PA0691 hypothetical protein PA0691 AlphaFold –
GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
0.789 No Hit N/A —
2131 PA0602 ABC transporter PA0602 AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0019810Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. GO:0019809Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. +14 total
0.789 No Hit N/A —
2132 PA0448 transcriptional regulator PA0448 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +36 total
0.789 No Hit N/A —
2133 PA0128 hypothetical protein PA0128 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.789 No Hit N/A —
2134 PA3116 aspartate-semialdehyde dehydrogenase usg, PA3116 Experimental + AlphaFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. +14 total
0.788 No Hit N/A —
2135 PA2901 hypothetical protein PA2901 Experimental + AlphaFold – – 0.788 No Hit N/A —
2136 PA2624 isocitrate dehydrogenase idh, PA2624 Experimental + AlphaFold
1.1.1.42
GO:0004450Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. GO:0046872Binding to a metal ion. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +25 total
0.788 No Hit N/A —
2137 PA2165 glycogen synthase PA2165, glgA AlphaFold
2.4.1.21
GO:0009011Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H+. GO:0004373Catalysis of the reaction: [(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H+ + UDP. GO:0005978The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. +14 total
0.788 No Hit N/A —
2138 PA5244 hypothetical protein PA5244 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.787 No Hit N/A —
2139 PA5063 ubiquinone/menaquinone biosynthesis methyltransferase PA5063, ubiE AlphaFold
2.1.1.163 2.1.1.201
GO:0008425Catalysis of the reaction: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+. GO:0043770Catalysis of the reaction: a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H+ + S-adenosyl-L-homocysteine. Reaction substrates can have varying polyprenyl side chain length. GO:0009060The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. +47 total
0.787 Hit 56.7% 3.23e-16
2140 PA4697 hypothetical protein PA4697 AlphaFold – – 0.787 No Hit N/A —
2141 PA4500 ABC transporter PA4500 AlphaFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1904680Enables the transfer of a peptide from one side of a membrane to the other. +36 total
0.787 No Hit N/A —
2142 PA2679 hypothetical protein PA2679 AlphaFold –
GO:0008757Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. GO:0032259The process in which a methyl group is covalently attached to a molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
0.787 No Hit N/A —
2143 PA2606 sulfur relay protein TusC tusC, PA2606 AlphaFold –
GO:1990228A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
0.787 No Hit N/A —
2144 PA2001 acetyl-CoA acetyltransferase atoB, PA2001 AlphaFold
2.3.1.9
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003985Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. +25 total
0.787 Hit 52.6% 6.18e-141
2145 PA1767 hypothetical protein PA1767 AlphaFold – – 0.787 No Hit N/A —
2146 PA1158 two-component sensor PA1158 AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +47 total
0.787 No Hit N/A —
2147 PA1030 hypothetical protein PA1030 Experimental + AlphaFold – – 0.787 No Hit N/A —
2148 PA0928 sensor/response regulator hybrid protein gacS, PA0928 Experimental + AlphaFold
2.7.13.3
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +811 total
0.787 No Hit N/A —
2149 PA0774 tRNA (mo5U34)-methyltransferase PA0774, cmoB AlphaFold
2.5.1.-
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0002098The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.
0.787 No Hit N/A —
2150 PA0343 hypothetical protein PA0343 AlphaFold – – 0.787 No Hit N/A —
Page of 223 · 5572 total proteins