Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2101 PA5111 lactoylglutathione lyase gloA3 ColabFold –
GO:0004462Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. GO:0046872Binding to a metal ion.
0.79 Hit 55.6% 5.66e-64
2102 PA4122 hypothetical protein PA4122 AlphaFold –
GO:0008704Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. GO:0018800Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. GO:0046872Binding to a metal ion. +25 total
0.79 Hit 37.1% 2.97e-38
2103 PA4038 hypothetical protein PA4038 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.79 No Hit N/A —
2104 PA3697 hypothetical protein PA3697 AlphaFold –
GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0080164Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
0.79 No Hit N/A —
2105 PA3549 alginate o-acetylase AlgJ algJ, PA3549 AlphaFold
2.3.1.-
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +25 total
0.79 No Hit N/A —
2106 PA3425 hypothetical protein PA3425 AlphaFold – – 0.79 No Hit N/A —
2107 PA2968 malonyl CoA-ACP transacylase fabD, PA2968 AlphaFold
2.3.1.39
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004314Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. +14 total
0.79 Hit 31.8% 9.03e-35
2108 PA2801 hypothetical protein PA2801 Experimental + AlphaFold –
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
0.79 No Hit N/A —
2109 PA1802 ATP-dependent protease ATP-binding subunit ClpX PA1802, clpX AlphaFold –
GO:0009376A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +710 total
0.79 Hit 52.3% 1.17e-103
2110 PA1783 nitrate transporter nasA, PA1783 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015112Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. GO:0015113Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other. +69 total
0.79 No Hit N/A —
2111 PA1757 phosphoserine phosphatase PA1757, thrH Experimental + AlphaFold
3.1.3.3
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046820Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. GO:0036424Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid. +69 total
0.79 No Hit N/A —
2112 PA1407 hypothetical protein PA1407 AlphaFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
0.79 No Hit N/A —
2113 PA1098 two-component sensor fleS, PA1098 AlphaFold
2.7.13.3
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +36 total
0.79 No Hit N/A —
2114 PA0868 peptidyl-tRNA hydrolase PA0868 AlphaFold
3.1.1.29
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004045Catalysis of the reaction: an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H+. GO:0043022Binding to a ribosome. +47 total
0.79 Hit 26.7% 5.29e-07
2115 PA0089 hypothetical protein PA0089 AlphaFold – – 0.79 No Hit N/A —
2116 PA5268 magnesium/cobalt transporter corA, PA5268 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015087Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other. GO:0015095Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. +69 total
0.789 No Hit N/A —
2117 PA5168 dicarboxylate transporter PA5168, dctQ AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015740The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms.
0.789 No Hit N/A —
2118 PA5144 hypothetical protein PA5144 AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.789 No Hit N/A —
2119 PA4849 hypothetical protein PA4849 AlphaFold – – 0.789 No Hit N/A —
2120 PA4490 hypothetical protein PA4490 Experimental + AlphaFold – – 0.789 No Hit N/A —
2121 PA4042 exodeoxyribonuclease VII small subunit PA4042, xseB AlphaFold
3.1.11.6
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009318An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. GO:0008855Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. +14 total
0.789 No Hit N/A —
2122 PA3624 protein-L-isoaspartate O-methyltransferase PA3624, pcm AlphaFold
2.1.1.77
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004719Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. GO:0032259The process in which a methyl group is covalently attached to a molecule. +25 total
0.789 Hit 39.3% 1.38e-18
2123 PA3306 hypothetical protein PA3306 AlphaFold –
GO:0035516Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA. GO:0051747Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA. GO:0008198Binding to a ferrous iron ion, Fe(II). +47 total
0.789 Hit 46.1% 4.34e-33
2124 PA2206 transcriptional regulator PA2206 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. +25 total
0.789 No Hit N/A —
2125 PA1248 alkaline protease secretion protein AprF aprF, PA1248 AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:1990281A protein complex that is capable of efflux transmembrane transporter activity. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +47 total
0.789 No Hit N/A —
Page of 223 · 5572 total proteins