Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2176 PA2455 hypothetical protein PA2455 AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.785 No Hit N/A —
2177 PA2237 biofilm formation protein PslG pslG, PA2237 Experimental + AlphaFold –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. GO:0071704OBSOLETE. The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
0.785 No Hit N/A —
2178 PA2008 fumarylacetoacetase PA2008, fahA AlphaFold
3.7.1.2
GO:0004334Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H+. GO:0046872Binding to a metal ion. GO:1902000The chemical reactions and pathways resulting in the breakdown of homogentisate. +47 total
0.785 Hit 64.9% 4.55e-11
2179 PA1497 transporter PA1497 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015204Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +14 total
0.785 Hit 42.5% 1.72e-06
2180 PA1321 protoheme IX farnesyltransferase cyoE ColabFold –
GO:0008495Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme O + diphosphate. GO:0006783The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). +14 total
0.785 Hit 36.8% 4.16e-19
2181 PA0709 hypothetical protein PA0709 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.785 No Hit N/A —
2182 PA5353 glycolate oxidase iron-sulfur subunit PA5353, glcF AlphaFold
1.1.99.14
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0019154Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate. +36 total
0.784 No Hit N/A —
2183 PA5212 hypothetical protein PA5212 AlphaFold – – 0.784 No Hit N/A —
2184 PA4935 30S ribosomal protein S6 PA4935, rpsF AlphaFold –
GO:0022627The small subunit of a ribosome located in the cytosol. GO:0070181Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +36 total
0.784 No Hit N/A —
2185 PA4308 hypothetical protein PA4308 AlphaFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.784 No Hit N/A —
2186 PA3816 O-acetylserine synthase PA3816, cysE AlphaFold
2.3.1.30
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009001Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. GO:0006535OBSOLETE. The chemical reactions and pathways resulting in the formation of cysteine from L- serine. +14 total
0.784 No Hit N/A —
2187 PA3643 lipid-A-disaccharide synthase PA3643, lpxB AlphaFold
2.4.1.182
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008915Catalysis of the reaction: a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + UDP + H+. GO:0005543Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. +14 total
0.784 No Hit N/A —
2188 PA3026 hypothetical protein PA3026 AlphaFold –
GO:0008609Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion. GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0008610The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. +25 total
0.784 Hit 37.4% 2.45e-29
2189 PA1597 hypothetical protein PA1597 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.784 No Hit N/A —
2190 PA1284 acyl-CoA dehydrogenase PA1284 AlphaFold
1.3.99.41
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
0.784 Hit 39.7% 7.53e-07
2191 PA0202 amidase PA0202 AlphaFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.784 Hit 31.6% 4.00e-22
2192 PA0101 hypothetical protein PA0101 AlphaFold – – 0.784 No Hit N/A —
2193 PA5301 transcriptional regulator PA5301 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0019810Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.783 No Hit N/A —
2194 PA4816 hypothetical protein PA4816 AlphaFold – – 0.783 No Hit N/A —
2195 PA4634 hypothetical protein PA4634 AlphaFold
3.4.-.-
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0003697Binding to single-stranded DNA. +58 total
0.783 No Hit N/A —
2196 PA3388 S-adenosylmethionine-dependent methyltransferase RcsF PA3388, rcsF Experimental + AlphaFold
2.1.1.-
GO:0089715Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine at position 37 = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine at position 37. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.783 Hit 46.3% 6.84e-38
2197 PA2086 epoxide hydrolase PA2086 Experimental + AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.783 Hit 34.9% 8.40e-13
2198 PA1930 chemotaxis transducer PA1930 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. +36 total
0.783 No Hit N/A —
2199 PA1762 hypothetical protein PA1762 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +14 total
0.783 No Hit N/A —
2200 PA1601 aldehyde dehydrogenase PA1601 AlphaFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.783 No Hit N/A —
Page of 223 · 5572 total proteins