Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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140 proteins Structure: ColabFold

Scoring formula None

Sorted by Druggability (descending)

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Structure: ColabFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA2048 hypothetical protein ColabFold – – 0.985 No Hit N/A —
2 PA3886a hypothetical protein ColabFold – – 0.974 No Hit N/A —
3 PA1281 adenosylcobinamide-GDP ribazoletransferase cobV ColabFold –
GO:0008818Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP. GO:0051073Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin.
0.964 No Hit N/A —
4 PA4853 Fis family transcriptional regulator fis ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
0.961 No Hit N/A —
5 PA2946 hypothetical protein ColabFold – – 0.952 No Hit N/A —
6 PA0701a AraC family transcriptional regulator ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.95 No Hit N/A —
7 PA4859 ABC transporter permease ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
0.949 No Hit N/A —
8 PA0077 type VI secretion protein IcmF icmF1 ColabFold – – 0.948 No Hit N/A —
9 PA4219 hypothetical protein ColabFold – – 0.947 No Hit N/A —
10 PA1414 hypothetical protein ColabFold – – 0.945 No Hit N/A —
11 PA5319 DNA repair protein RadC radC ColabFold – – 0.944 No Hit N/A —
12 PA4332 hypothetical protein ColabFold – – 0.943 No Hit N/A —
13 PA3963a hypothetical protein ColabFold – – 0.942 No Hit N/A —
14 PA1833a alpha/beta hydrolase ColabFold – – 0.94 No Hit N/A —
15 PA2312a hypothetical protein ColabFold – – 0.934 No Hit N/A —
16 PA5024 hypothetical protein ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.933 No Hit N/A —
17 PA3969a hypothetical protein ColabFold – – 0.923 No Hit N/A —
18 PA5252a hypothetical protein ColabFold – – 0.918 No Hit N/A —
19 PA0538 disulfide bond formation protein dsbB ColabFold –
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds.
0.914 No Hit N/A —
20 PA3865a hypothetical protein ColabFold – – 0.905 No Hit N/A —
21 PA3013 3-ketoacyl-CoA thiolase foaB ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0006631The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. +36 total
0.899 Hit 47.5% 2.54e-63
22 PA4470 fumarate hydratase fumC1 ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. +36 total
0.894 Hit 44.1% 8.58e-112
23 PA0103a hypothetical protein ColabFold – – 0.893 No Hit N/A —
24 PA3574a copper chaperone CopZ ColabFold –
GO:0046872Binding to a metal ion.
0.89 No Hit N/A —
25 PA3333 3-oxoacyl-ACP synthase III fabH2 ColabFold –
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0004315Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein].
0.886 No Hit N/A —
Page of 6 · 140 total proteins