Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA2072 hypothetical protein PA2072 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
0.201 No Hit N/A —
2 PA4543 hypothetical protein PA4543 AlphaFold
2.4.2.1 3.5.4.4 2.4.2.28
GO:0004000Catalysis of the reaction: adenosine + H2O = inosine + NH4+. GO:0005507Binding to a copper (Cu) ion. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.201 Hit 36.1% 3.34e-10
3 PA0697 hypothetical protein PA0697 AlphaFold – – 0.202 No Hit N/A —
4 PA3818 type III secretion system regulator SuhB suhB, PA3818 Experimental + AlphaFold
3.1.3.25
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0046872Binding to a metal ion. +69 total
0.203 Hit 47.1% 2.43e-14
5 PA1493 sulfate ABC transporter substrate-binding protein PA1493, cysP AlphaFold –
GO:0005615OBSOLETE. That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0140104Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. +36 total
0.204 No Hit N/A —
6 PA5452 phosphomannose isomerase/mannose-1-phosphate guanylyl transferase PA5452, wbpW AlphaFold
2.7.7.13 5.3.1.8
GO:0005525Binding to GTP, guanosine triphosphate. GO:0004475Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. GO:0004476Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. +811 total
0.204 No Hit N/A —
7 PA3616 recombination regulator RecX recX, PA3616 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006282Any process that modulates the frequency, rate or extent of DNA repair. GO:0009432An error-prone process for repairing damaged microbial DNA.
0.211 No Hit N/A —
8 PA0075 serine/threonine phosphatase PA0075, pppA Experimental + AlphaFold –
GO:0046872Binding to a metal ion. GO:0004722Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. GO:0050709Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. +25 total
0.212 No Hit N/A —
9 PA4384 hypothetical protein PA4384 AlphaFold – – 0.213 No Hit N/A —
10 PA4421 cell division protein MraZ mraZ, PA4421 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009295The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +47 total
0.213 No Hit N/A —
11 PA4623 hypothetical protein PA4623 AlphaFold – – 0.215 No Hit N/A —
12 PA4740 polynucleotide phosphorylase PA4740, pnp AlphaFold
2.7.7.8
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0000287Binding to a magnesium (Mg) ion. +69 total
0.215 Hit 44.3% 1.46e-06
13 PA0357 formamidopyrimidine-DNA glycosylase fpg, PA0357, mutM AlphaFold
3.2.2.23 4.2.99.18
GO:0034039Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. GO:0140078Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. GO:0003684Binding to damaged DNA. +1013 total
0.216 No Hit N/A —
14 PA0263 secreted protein Hcp PA5267, hcpB, hcpA, hcpC Experimental + AlphaFold – – 0.217 No Hit N/A —
15 PA0664 hypothetical protein PA0664 AlphaFold – – 0.217 No Hit N/A —
16 PA4404 hypothetical protein mepM_1, PA4404 AlphaFold –
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.217 No Hit N/A —
17 PA1204 NAD(P)H-dependent FMN reductase PA1204 Experimental + AlphaFold
1.-.-.-
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0052873Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+. +58 total
0.219 No Hit N/A —
18 PA3152 imidazole glycerol phosphate synthase subunit HisH hisH, hisH2, PA3152 AlphaFold
4.3.2.10 3.5.1.2
GO:0009382Complex that possesses imidazoleglycerol-phosphate synthase activity. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. +47 total
0.22 No Hit N/A —
19 PA3204 two-component response regulator PA3204 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +47 total
0.22 No Hit N/A —
20 PA4397 2-dehydropantoate 2-reductase panE, PA4397 Experimental + AlphaFold
1.1.1.169
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008677Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. +25 total
0.222 No Hit N/A —
21 PA5240 thioredoxin trx, trxA, PA5240 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. +14 total
0.222 Hit 37.3% 1.15e-14
22 PA5281 hydrolase PA5281 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
0.223 Hit 49.1% 1.15e-07
23 PA4478 hypothetical protein PA4478 AlphaFold
3.6.1.9
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0036218Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate. GO:0047429Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. +25 total
0.226 Hit 39.2% 1.30e-30
24 PA3115 motility protein FimV fimV, PA3115 Experimental + AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0044096A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. +25 total
0.228 No Hit N/A —
25 PA3223 FMN-dependent NADH-azoreductase PA3223, azoR3 AlphaFold
1.6.5.- 1.7.1.17
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016652Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. +25 total
0.229 Hit 31.5% 5.76e-06
Page of 223 · 5572 total proteins