Proteins

Genome: NZ_AP023069.1

Description: Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome

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62 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
51 HT085_RS00165 class II fructose-bisphosphate aldolase fda, fba Experimental + AlphaFold
4.1.2.13
GO:0004332Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate. GO:0008270Binding to a zinc ion (Zn). GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
No pocket No Hit — —
52 HT085_RS00035 DpnI domain-containing protein dpnC AlphaFold – – No pocket No Hit — —
53 HT085_RS00330 acyltransferase family protein oatA_1, oatA_2 AlphaFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016788Catalysis of the hydrolysis of any ester bond. +14 total
No pocket No Hit — —
54 HT085_RS00185 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB miaB AlphaFold
2.8.4.3
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046872Binding to a metal ion. +14 total
No pocket Hit — —
55 HT085_RS00255 ComF family protein AlphaFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
No pocket No Hit — —
56 HT085_RS00225 acetyl-CoA carboxylase biotin carboxylase subunit accC AlphaFold
6.3.4.14
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. GO:0004075Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. +14 total
No pocket Hit — —
57 HT085_RS00305 N-acetylmuramate alpha-1-phosphate uridylyltransferase MurU rmlA2, murU AlphaFold –
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
No pocket Hit — —
58 HT085_RS00315 formate--tetrahydrofolate ligase fhs AlphaFold
6.3.4.3
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004329Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. GO:0035999The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules.
No pocket Hit — —
59 HT085_RS00125 prolyl oligopeptidase family serine peptidase AlphaFold –
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No pocket Hit — —
60 HT085_RS00095 protein-L-isoaspartate O-methyltransferase family protein pcm AlphaFold –
GO:0004719Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No pocket Hit — —
61 HT085_RS00345 opacity family porin ColabFold – – No pocket No Hit — —
62 HT085_RS00010 DNA polymerase III subunit beta dnaN AlphaFold –
GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. +36 total
No pocket No Hit — —
Page of 3 · 62 total proteins