Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4526 VK055_4139 pepP pepP AlphaFold + ColabFold
3.4.11.9
GO:0030145Binding to a manganese ion (Mn). GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.191 Hit 39.3% 9.95e-24
4527 VK055_4286 RNA pyrophosphohydrolase nudH AlphaFold + ColabFold
3.6.1.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034353Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end. +14 total
0.19 No Hit 0.0% —
4528 VK055_3969 siderophore-interacting FAD-binding domain protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.19 No Hit 0.0% —
4529 VK055_3821 septum formation protein Maf maf2 AlphaFold + ColabFold
3.6.1.9
GO:0047429Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0036218Catalysis of the reaction: dTTP + H2O = dTMP + H+ + diphosphate. +25 total
0.19 Hit 43.2% 8.03e-33
4530 VK055_3662 hypothetical protein AlphaFold + ColabFold – – 0.19 No Hit 0.0% —
4531 VK055_2387 hypothetical protein AlphaFold + ColabFold – – 0.19 No Hit 0.0% —
4532 VK055_5049 bacterial regulatory, arsR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.189 No Hit 0.0% —
4533 VK055_1088 hypothetical protein AlphaFold + ColabFold – – 0.189 No Hit 0.0% —
4534 VK055_3211 hypothetical protein AlphaFold + ColabFold – – 0.188 No Hit 0.0% —
4535 VK055_5150 C-5 cytosine-specific DNA methylase family protein ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule.
0.187 No Hit 0.0% —
4536 VK055_4554 flavin reductase domain protein, FMN-binding protein ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
0.187 No Hit 0.0% —
4537 VK055_4276 uxuR transcriptional repressor AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.187 No Hit 0.0% —
4538 VK055_4061 hypothetical protein AlphaFold + ColabFold – – 0.187 No Hit 0.0% —
4539 VK055_2727 polysaccharide pyruvyl transferase family protein Experimental + ColabFold – – 0.187 No Hit 0.0% —
4540 VK055_0810 hypothetical protein ColabFold – – 0.187 No Hit 0.0% —
4541 VK055_4393 hypothetical protein AlphaFold + ColabFold – – 0.186 No Hit 0.0% —
4542 VK055_3549 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.186 Hit 42.0% 6.44e-09
4543 VK055_2547 dpiA-phosphorylated DNA binding transcriptional dual regulator dpiA2 AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.186 No Hit 0.0% —
4544 VK055_1406 bacterial regulatory, tetR family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.186 No Hit 0.0% —
4545 VK055_1238 exodeoxyribonuclease III xth AlphaFold + ColabFold
3.1.11.2
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008311Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +47 total
0.186 Hit 30.2% 6.47e-11
4546 VK055_0291 nlpC/P60 family protein AlphaFold + ColabFold –
GO:0008234Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.186 No Hit 0.0% —
4547 VK055_4091 hypothetical protein AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.184 Hit 34.2% 5.93e-11
4548 VK055_1391 hypothetical protein ColabFold – – 0.184 No Hit 0.0% —
4549 VK055_1163 hutD family protein AlphaFold + ColabFold – – 0.184 No Hit 0.0% —
4550 VK055_4570 tRNA (guanine(37)-N(1))-methyltransferase trmD AlphaFold + ColabFold
2.1.1.228
GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0052906Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.183 No Hit 0.0% —
Page of 204 · 5081 total proteins