Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4576 VK055_2434 carbonic anhydrase 2 yadF AlphaFold DB model + ColabFold model
4.2.1.1
GO:0008270Binding to a zinc ion (Zn). GO:0015976A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. GO:0004089Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O.
Mapped 1 0.054 0.175 No Hit 0.0% —
4577 VK055_1594 amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.054 0.194 No Hit 0.0% —
4578 VK055_0958 putative aTP-binding component of a transport system AlphaFold DB model + ColabFold model – – No map 0.054 0.599 No Hit 0.0% —
4579 VK055_0322 feS assembly protein SufD sufD AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
No map 0.054 0.331 No Hit 0.0% —
4580 VK055_0302 transglycosylase associated family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.054 0.974 No Hit 0.0% —
4581 VK055_0203 impA-related N-terminal family protein impA2 AlphaFold DB model + ColabFold model – – No map 0.054 0.832 No Hit 0.0% —
4582 VK055_0189 sel1 repeat family protein AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein.
No map 0.054 0.358 No Hit 0.0% —
4583 VK055_4553 bacterial regulatory helix-turn-helix, AraC family protein rarA AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map N/A 0.053 No Hit 0.0% —
4584 VK055_4356 L-fucose mutarotase fucU AlphaFold DB model + ColabFold model
5.1.3.29
GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0042354The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. +69 total
Mapped 1 0.053 0.415 Hit 47.2% 2.05e-36
4585 VK055_4034 qseB transcriptional activator AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +47 total
No map 0.053 0.72 No Hit 0.0% —
4586 VK055_3792 bacterial transferase hexapeptide family protein AlphaFold DB model + ColabFold model – – No map 0.053 0.27 No Hit 0.0% —
4587 VK055_3788 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.053 0.569 No Hit 0.0% —
4588 VK055_3772 ribosomal protein S5 rpsE AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0015935The smaller of the two subunits of a ribosome. GO:0003723Binding to an RNA molecule or a portion thereof. +25 total
No map 0.053 0.26 Hit 29.2% 4.60e-08
4589 VK055_0882 rhodanese-like domain protein AlphaFold DB model + ColabFold model – – No map 0.053 0.334 No Hit 0.0% —
4590 VK055_0980 putative aTP synthase subunit epsilon AlphaFold DB model + ColabFold model – – No map 0.052 0.591 No Hit 0.0% —
4591 VK055_3407 2-aminoethylphosphonate ABC transport system, membrane component PhnV phnV AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.051 0.744 No Hit 0.0% —
4592 VK055_2730 putative transposase protein ColabFold model – – No map N/A 0.051 No Hit 0.0% —
4593 VK055_1881 universal stress protein UP12 AlphaFold DB model + ColabFold model – – No map 0.051 0.539 No Hit 0.0% —
4594 VK055_1754 regulator of acid resistance, influenced by indole ymgB AlphaFold DB model + ColabFold model –
GO:0071468Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
No map 0.051 0.077 No Hit 0.0% —
4595 VK055_0935 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.051 No Hit 0.0% —
4596 VK055_0477 riboflavin synthase, alpha subunit ribE AlphaFold DB model + ColabFold model
2.5.1.9
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004746Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
Chokepoint 1 0.051 0.27 No Hit 0.0% —
4597 VK055_4353 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.050 0.5 No Hit 0.0% —
4598 VK055_3689 pimelyl-[acyl-carrier protein] methyl ester esterase bioH Experimental + ColabFold model –
GO:0052689Catalysis of the hydrolysis of a carboxylic ester bond. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
No map 0.050 0.553 Hit 30.2% 2.30e-06
4599 VK055_3425 putative efflux pump outer membrane protein ttgC AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. +25 total
No map 0.050 0.554 No Hit 0.0% —
4600 VK055_1964 amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.050 0.641 No Hit 0.0% —
Page of 204 · 5081 total proteins