Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4551 VK055_4487 alanine--tRNA ligase alaS AlphaFold + ColabFold
6.1.1.7
GO:0043039The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006419The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA. +1013 total
0.183 Hit 58.1% 1.90e-10
4552 VK055_2706 periplasmic copper/silver-binding protein cusF AlphaFold + ColabFold – – 0.183 No Hit 0.0% —
4553 VK055_2057 citrate (Si)-synthase gltA2 AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004108OBSOLETE. Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. +25 total
0.183 Hit 22.2% 6.64e-11
4554 VK055_1303 EAL domain protein AlphaFold + ColabFold – – 0.183 No Hit 0.0% —
4555 VK055_4640 scaffold protein involved in iron-sulfur cluster assembly AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0005506Binding to an iron (Fe) ion. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.
0.181 Hit 75.4% 2.18e-69
4556 VK055_4600 srmB, DEAD-box RNA helicase AlphaFold + ColabFold
3.6.4.13
GO:0000027The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. +36 total
0.181 Hit 56.5% 2.89e-14
4557 VK055_3746 sulfur relay protein TusB/DsrH dsrH AlphaFold + ColabFold –
GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990228A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor).
0.181 No Hit 0.0% —
4558 VK055_1767 phosphoglyceromutase 1 gpmA AlphaFold + ColabFold
5.4.2.11
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0016868Catalysis of the transfer of a phosphate group from one position to another within a single molecule. +25 total
0.181 Hit 58.1% 3.47e-101
4559 VK055_1224 chbR transcriptional regulator ChbR transcriptional dual regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.181 No Hit 0.0% —
4560 VK055_1157 bacterial extracellular solute-binding, 5 Middlefamily protein AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
0.18 No Hit 0.0% —
4561 VK055_3193 thioredoxin trxA2 AlphaFold + ColabFold –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell.
0.179 Hit 41.9% 9.27e-18
4562 VK055_4517 putative cytoplasmic protein AlphaFold + ColabFold – – 0.178 No Hit 0.0% —
4563 VK055_4067 fimbrial family protein AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.178 No Hit 0.0% —
4564 VK055_2342 endonuclease/Exonuclease/phosphatase family protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
0.178 No Hit 0.0% —
4565 VK055_2134 putative dTDP-glucose pyrophosphorylase AlphaFold + ColabFold – – 0.178 No Hit 0.0% —
4566 VK055_1930 ferric vibriobactin ABC transporter, ATP-bindingprotein fepC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.178 Hit 32.0% 4.68e-15
4567 VK055_1256 L-asparaginase I AlphaFold + ColabFold
3.5.1.1
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0004067Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH4+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.178 Hit 58.6% 6.13e-34
4568 VK055_0965 3-oxoadipate CoA-transferase subunit A pcaI AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.178 Hit 48.2% 4.34e-21
4569 VK055_0727 purine catabolism protein pucG pucG AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008453Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. GO:0004760Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. +14 total
0.178 Hit 33.0% 2.24e-65
4570 VK055_4519 hypothetical protein AlphaFold + ColabFold – – 0.177 No Hit 0.0% —
4571 VK055_1718 molybdopterin converting factor, subunit 1 moaD AlphaFold + ColabFold –
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
0.177 No Hit 0.0% —
4572 VK055_4133 ribose 5-phosphate isomerase A rpiA AlphaFold + ColabFold
5.3.1.6
GO:0004751Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate. GO:0009052The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.176 Hit 37.1% 8.58e-31
4573 VK055_3584 hypothetical protein AlphaFold + ColabFold – – 0.176 No Hit 0.0% —
4574 VK055_2613 ybaK / prolyl-tRNA synthetases associated domainprotein AlphaFold + ColabFold –
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA.
0.176 No Hit 0.0% —
4575 VK055_0903 hypothetical protein ColabFold – – 0.176 No Hit 0.0% —
Page of 204 · 5081 total proteins