Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4601 VK055_1175 TPR repeat family protein AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0008653The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0009898The leaflet of the plasma membrane that faces the cytoplasm, including any protein embedded in, attached to, or peripherally associated with it. +25 total
0.171 No Hit 0.0% —
4602 VK055_0388 hypothetical protein AlphaFold + ColabFold – – 0.171 No Hit 0.0% —
4603 VK055_4516 hypothetical protein AlphaFold + ColabFold –
GO:0043022Binding to a ribosome. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.17 No Hit 0.0% —
4604 VK055_1450 histidine phosphatase super family protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0050308Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.
0.17 No Hit 0.0% —
4605 VK055_4450 hydrogenase accessory protein HypB hypB AlphaFold + ColabFold –
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0016151Binding to a nickel (Ni) cation. GO:0051604Any process leading to the attainment of the full functional capacity of a protein. +25 total
0.168 No Hit 0.0% —
4606 VK055_3210 competence protein ComM comM AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0032508OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. +14 total
0.168 Hit 23.9% 8.65e-07
4607 VK055_0103 tail-specific protease AlphaFold + ColabFold
3.4.21.102
GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. +47 total
0.168 No Hit 0.0% —
4608 VK055_4217 arsenate reductase arsC AlphaFold + ColabFold –
GO:0008794Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
0.167 No Hit 0.0% —
4609 VK055_3588 endo-1,4-D-glucanase AlphaFold + ColabFold
3.2.1.4
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0008810Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. +14 total
0.167 No Hit 0.0% —
4610 VK055_2884 23S rRNA (guanosine-2'-O-)-methyltransferase rlmB rlmB AlphaFold + ColabFold
2.1.1.185
GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
0.167 Hit 30.5% 2.58e-18
4611 VK055_4814 lysine-arginine-ornithine-binding periplasmic family protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.166 No Hit 0.0% —
4612 VK055_4293 prepilin-type N-terminal cleavage/methylation domain protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.166 No Hit 0.0% —
4613 VK055_2829 hypothetical protein AlphaFold + ColabFold – – 0.166 No Hit 0.0% —
4614 VK055_2826 hypothetical protein AlphaFold + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0019213Catalysis of the hydrolysis of an acetyl group from a substrate molecule. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +14 total
0.166 No Hit 0.0% —
4615 VK055_2315 alpha/beta hydrolase family protein AlphaFold + ColabFold
3.1.1.1
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0106435Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+.
0.166 No Hit 0.0% —
4616 VK055_5153 hypothetical protein AlphaFold + ColabFold –
GO:0005694A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
0.165 No Hit 0.0% —
4617 VK055_2488 D-fructose-responsive transcription factor family protein AlphaFold + ColabFold –
GO:0009750Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
0.165 No Hit 0.0% —
4618 VK055_1888 methionine aminotransferase, PLP-dependent AlphaFold + ColabFold –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +25 total
0.165 Hit 34.2% 9.98e-35
4619 VK055_1127 hypothetical protein AlphaFold + ColabFold – – 0.165 No Hit 0.0% —
4620 VK055_2578 transcriptional regulatory, C terminal family protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +69 total
0.164 No Hit 0.0% —
4621 VK055_3742 peptidyl-prolyl cis-trans isomerase in protein folding AlphaFold + ColabFold
5.2.1.8
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
0.163 Hit 52.5% 1.42e-17
4622 VK055_2953 hypothetical protein AlphaFold + ColabFold – – 0.163 No Hit 0.0% —
4623 VK055_2883 hypothetical protein AlphaFold + ColabFold – – 0.163 No Hit 0.0% —
4624 VK055_2832 hypothetical protein AlphaFold + ColabFold – – 0.163 No Hit 0.0% —
4625 VK055_2735 hypothetical protein ColabFold – – 0.163 No Hit 0.0% —
Page of 204 · 5081 total proteins