Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 / 5081 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4601 VK055_1165 NADH-dependent enoyl-(acyl carrier protein) reductase fabI Experimental + ColabFold model
1.3.1.9
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0004318Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
No map 0.050 0.532 Hit 30.9% 2.07e-07
4602 VK055_0668 mg2+ transport protein mgtC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.050 0.788 No Hit 0.0% —
4603 VK055_5113 hemolysin expression modulating family protein ColabFold model – – No map N/A 0.049 No Hit 0.0% —
4604 VK055_4498 S-ribosylhomocysteine lyase luxS AlphaFold DB model + ColabFold model
4.4.1.21
GO:0005506Binding to an iron (Fe) ion. GO:0043768Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine. GO:0009372The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms. +14 total
Chokepoint 1 0.049 0.448 No Hit 0.0% —
4605 VK055_3193 thioredoxin trxA2 AlphaFold DB model + ColabFold model –
GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell.
No map 0.049 0.179 Hit 41.9% 9.27e-18
4606 VK055_3060 bacterial transferase hexapeptide family protein AlphaFold DB model + ColabFold model – – No map 0.049 0.258 No Hit 0.0% —
4607 VK055_2474 cell division protein FtsQ ftsQ AlphaFold DB model + ColabFold model –
GO:0090529The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.049 0.438 No Hit 0.0% —
4608 VK055_2416 type II secretion system protein L gspL AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0009276The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. +14 total
No map 0.049 0.733 No Hit 0.0% —
4609 VK055_0565 putative inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.049 0.946 No Hit 0.0% —
4610 VK055_4197 hypothetical protein ColabFold model – – No map 0.048 0.414 No Hit 0.0% —
4611 VK055_3320 D-ribose utilization rbsD AlphaFold DB model + ColabFold model
5.4.99.62
GO:0048029Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. +47 total
No map 0.048 0.366 No Hit 0.0% —
4612 VK055_3050 putative cheW domain protein AlphaFold DB model + ColabFold model – – No map N/A 0.048 No Hit 0.0% —
4613 VK055_2382 translation elongation factor Ts tsf AlphaFold DB model + ColabFold model –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0005515Binding to a protein. GO:0006414The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. +14 total
No map 0.048 0.664 Hit 36.1% 3.51e-12
4614 VK055_1860 DNA polymerase III, delta subunit holA AlphaFold DB model + ColabFold model
2.7.7.7
GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0009360The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. +25 total
No map 0.048 0.622 No Hit 0.0% —
4615 VK055_4835 lrhA transcriptional repressor LrhA transcriptional dual regulator AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.047 0.155 No Hit 0.0% —
4616 VK055_4286 RNA pyrophosphohydrolase nudH AlphaFold DB model + ColabFold model
3.6.1.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034353Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end. +14 total
No map 0.047 0.19 No Hit 0.0% —
4617 VK055_3945 conserved inner membrane protein yqjA ColabFold model – – No map 0.047 0.332 No Hit 0.0% —
4618 VK055_3906 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.047 0.753 No Hit 0.0% —
4619 VK055_2891 hflC protein hflC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0052547Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. +14 total
No map 0.047 0.367 Hit 28.1% 7.97e-07
4620 VK055_2095 recombination protein RecR recR AlphaFold DB model + ColabFold model –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
No map 0.047 0.969 No Hit 0.0% —
4621 VK055_5177 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.046 0.101 No Hit 0.0% —
4622 VK055_4225 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.046 0.365 No Hit 0.0% —
4623 VK055_2987 sel1 repeat family protein Experimental + ColabFold model –
GO:0005515Binding to a protein.
No map 0.046 0.343 No Hit 0.0% —
4624 VK055_2613 ybaK / prolyl-tRNA synthetases associated domainprotein AlphaFold DB model + ColabFold model –
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA.
No map 0.046 0.176 No Hit 0.0% —
4625 VK055_0132 septum site-determining protein MinC minC AlphaFold DB model + ColabFold model –
GO:0000902The developmental process in which the size or shape of a cell is generated and organized. GO:0051302Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. GO:1901891Any process that modulates the frequency, rate or extent of cell septum assembly. +25 total
No map 0.046 0.818 No Hit 0.0% —
Page of 204 · 5081 total proteins