Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4626 VK055_0113 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005384Enables the transfer of manganese (Mn) ions from one side of a membrane to the other.
No map 0.046 0.463 No Hit 0.0% —
4627 VK055_0024 yedD-like family protein Experimental + ColabFold model – – No map 0.046 0.382 No Hit 0.0% —
4628 VK055_5059 HPP family protein AlphaFold DB model + ColabFold model – – No map 0.045 0.221 No Hit 0.0% —
4629 VK055_1205 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.045 0.758 No Hit 0.0% —
4630 VK055_0482 sodB sodB AlphaFold DB model + ColabFold model
1.15.1.1
GO:0004784Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +25 total
Mapped 2 0.045 0.051 Hit 58.3% 2.27e-07
4631 VK055_0165 ABC transporter, substrate binding protein AlphaFold DB model + ColabFold model –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map 0.045 0.348 No Hit 0.0% —
4632 VK055_0097 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.045 0.477 No Hit 0.0% —
4633 VK055_4379 tRNA pseudouridine synthase C family protein AlphaFold DB model + ColabFold model –
GO:0044010A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
No map 0.044 0.46 No Hit 0.0% —
4634 VK055_4310 cob(I)alamin adenosyltransferase AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008817Catalysis of the reaction: 2 ATP + 2 corrinoid + reduced [electron-transfer flavoprotein] = 2 adenosylcorrinoid + 3 H+ + oxidized [electron-transfer flavoprotein] + 2 triphosphate. The corrinoid can be cob(II)yrinate a,c diamide, cob(II)inamide or cob(II)alamin.
Chokepoint 7 0.044 0.658 Hit 45.2% 2.07e-11
4635 VK055_4167 3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG ubiX AlphaFold DB model + ColabFold model
2.5.1.129
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0106141Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2.
No map 0.044 0.47 No Hit 0.0% —
4636 VK055_4027 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.044 0.15 No Hit 0.0% —
4637 VK055_3253 regulator of ribonuclease activity A rraA AlphaFold DB model + ColabFold model –
GO:0008428Binds to and stops, prevents or reduces the activity of ribonuclease. GO:0051252Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
No map 0.044 0.096 No Hit 0.0% —
4638 VK055_3028 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.044 0.312 No Hit 0.0% —
4639 VK055_2673 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.044 0.666 No Hit 0.0% —
4640 VK055_2354 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.044 0.655 No Hit 0.0% —
4641 VK055_1737 histidine utilization repressor hutC AlphaFold DB model + ColabFold model –
GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0006547OBSOLETE. The chemical reactions and pathways involving L-histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
No map 0.044 0.528 No Hit 0.0% —
4642 VK055_1705 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.044 No Hit 0.0% —
4643 VK055_1098 hypothetical protein ColabFold model – – No map 0.044 0.42 No Hit 0.0% —
4644 VK055_3307 molybdopterin-guanine dinucleotide biosynthesis protein B mobB AlphaFold DB model + ColabFold model –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
Mapped 1 0.043 0.437 No Hit 0.0% —
4645 VK055_2029 hlyD secretion family protein AlphaFold DB model + ColabFold model – – No map 0.043 0.882 No Hit 0.0% —
4646 VK055_1712 inner membrane YbhQ family protein ColabFold model – – No map 0.043 0.901 No Hit 0.0% —
4647 VK055_4248 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.042 0.823 No Hit 0.0% —
4648 VK055_4081 that protects iron-sulfur proteins against oxidative damage yggX AlphaFold DB model + ColabFold model –
GO:0005506Binding to an iron (Fe) ion. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0034599Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
No map 0.042 0.836 No Hit 0.0% —
4649 VK055_3988 hypothetical protein Experimental + ColabFold model – – No map 0.042 0.634 No Hit 0.0% —
4650 VK055_3069 manX manX2 Experimental + ColabFold model
2.7.1.206
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.042 0.153 No Hit 0.0% —
Page of 204 · 5081 total proteins