Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4626 VK055_2654 5-carboxymethyl-2-hydroxymuconate Delta-isomerase hpcD AlphaFold + ColabFold –
GO:0008704Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
0.163 No Hit 0.0% —
4627 VK055_0087 protease II AlphaFold + ColabFold
3.4.21.83
GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
0.163 Hit 27.0% 7.06e-48
4628 VK055_5000 efflux transporter, RND family, MFP subunit AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.162 No Hit 0.0% —
4629 VK055_2830 glycine-rich SFCGS family protein AlphaFold + ColabFold – – 0.162 No Hit 0.0% —
4630 VK055_2622 chromosome replication; initiation and chain elongation dnaC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. +36 total
0.162 No Hit 0.0% —
4631 VK055_1449 yccJ-like family protein AlphaFold + ColabFold – – 0.162 No Hit 0.0% —
4632 VK055_1274 short chain dehydrogenase family protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.162 Hit 39.8% 4.40e-06
4633 VK055_2381 UMP kinase pyrH AlphaFold + ColabFold
2.7.4.22
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006221The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0009041OBSOLETE. Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. +58 total
0.161 No Hit 0.0% —
4634 VK055_4269 cupin 2, conserved barrel domain protein AlphaFold + ColabFold – – 0.16 No Hit 0.0% —
4635 VK055_1503 AAA domain protein AlphaFold + ColabFold
3.4.21.53
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004176Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. +25 total
0.16 No Hit 0.0% —
4636 VK055_1313 hypothetical protein AlphaFold + ColabFold – – 0.16 No Hit 0.0% —
4637 VK055_4693 arsenate reductase arsC2 AlphaFold + ColabFold
1.20.4.1
GO:0008794Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
0.159 No Hit 0.0% —
4638 VK055_3186 glucose-1-phosphate thymidylyltransferase rfbA AlphaFold + ColabFold
2.7.7.24
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008879Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose. GO:0045226OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. +14 total
0.159 Hit 33.7% 6.45e-10
4639 VK055_3100 thiazole biosynthesis adenylyltransferase ThiF thiF AlphaFold + ColabFold –
GO:0008641Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.159 Hit 41.0% 5.49e-42
4640 VK055_2989 hypothetical protein AlphaFold + ColabFold – – 0.159 No Hit 0.0% —
4641 VK055_2449 putative secreted protein AlphaFold + ColabFold – – 0.159 No Hit 0.0% —
4642 VK055_2420 ATP-dependent helicase HrpB hrpB AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. +14 total
0.159 Hit 40.8% 5.56e-19
4643 VK055_2072 putative outer membrane protein AlphaFold + ColabFold – – 0.159 No Hit 0.0% —
4644 VK055_2700 cupin superfamily protein AlphaFold + ColabFold –
GO:0016706Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. GO:0046872Binding to a metal ion.
0.158 No Hit 0.0% —
4645 VK055_0844 carboxymuconolactone decarboxylase family protein AlphaFold + ColabFold –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
0.158 No Hit 0.0% —
4646 VK055_4042 2,5-diketo-D-gluconic acid reductase A dkgA AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
0.157 Hit 47.2% 4.62e-12
4647 VK055_1717 molybdopterin synthase large subunit AlphaFold + ColabFold
2.8.1.12
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0030366Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.
0.157 Hit 33.3% 8.42e-19
4648 VK055_0717 acetyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.157 No Hit 0.0% —
4649 VK055_3472 guanylate kinase gmk AlphaFold + ColabFold
2.7.4.8
GO:0004385Catalysis of the reaction: ATP + GMP = ADP + GDP. GO:0006163The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.156 Hit 52.2% 1.84e-06
4650 VK055_4835 lrhA transcriptional repressor LrhA transcriptional dual regulator AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.155 No Hit 0.0% —
Page of 204 · 5081 total proteins