Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4776 VK055_5180 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.025 0.552 No Hit 0.0% —
4777 VK055_5175 phage gp6-like head-tail connector family protein AlphaFold DB model + ColabFold model – – No map 0.025 0.209 No Hit 0.0% —
4778 VK055_5092 transglycosylase SLT domain protein ColabFold model – – No map 0.025 0.236 No Hit 0.0% —
4779 VK055_4148 ahpC/TSA family protein AlphaFold DB model + ColabFold model –
GO:0016209Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.025 0.282 No Hit 0.0% —
4780 VK055_3933 LTXXQ motif family protein AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.025 0.857 No Hit 0.0% —
4781 VK055_2985 molybdopterin oxidoreductase family protein AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
No map 0.025 0.258 No Hit 0.0% —
4782 VK055_1788 cyd operon protein YbgT AlphaFold DB model + ColabFold model – – No map 0.025 0.861 No Hit 0.0% —
4783 VK055_1535 ca2+-binding protein involved in chromosome partitioning mukF AlphaFold DB model + ColabFold model –
GO:0005509Binding to a calcium ion (Ca2+). GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
No map 0.025 0.889 No Hit 0.0% —
4784 VK055_1088 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.025 0.189 No Hit 0.0% —
4785 VK055_0962 3-carboxy-cis,cis-muconate cycloisomerase pcaB AlphaFold DB model + ColabFold model
5.5.1.2
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019619The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. GO:0047472Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H+. +14 total
Chokepoint 1 0.025 0.55 Hit 30.7% 1.03e-11
4786 VK055_0902 hsp20/alpha crystallin family protein AlphaFold DB model + ColabFold model – – No map 0.025 0.357 No Hit 0.0% —
4787 VK055_0147 lytic murein transglycosylase E mltE AlphaFold DB model + ColabFold model
4.2.2.n1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000270The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008933Catalysis of the cleavage of a peptidoglycan chain into a peptidoglycan chain with N-acetyl-1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end. Includes endolytic transglycosylase activity that fragments the glycan chain internally and exolytic transgylcosylase activity that cleaves a terminal disaccharide from the end of the glycan strand. +25 total
Mapped 6 0.025 0.82 No Hit 0.0% —
4788 VK055_5088 putative surface exclusion lipoprotein AlphaFold DB model + ColabFold model – – No map 0.024 0.222 No Hit 0.0% —
4789 VK055_4158 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.024 0.027 No Hit 0.0% —
4790 VK055_2969 bacterial phosphonate metabolism family protein AlphaFold DB model + ColabFold model –
GO:0019634The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
No map 0.024 0.536 No Hit 0.0% —
4791 VK055_2965 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.024 0.32 No Hit 0.0% —
4792 VK055_2809 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
No map 0.024 0.201 Hit 47.4% 4.98e-18
4793 VK055_2799 ribonuclease E inhibitor protein B yjgD AlphaFold DB model + ColabFold model – – No map 0.024 0.575 No Hit 0.0% —
4794 VK055_2466 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000917The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. +14 total
No map 0.024 0.68 No Hit 0.0% —
4795 VK055_1998 hypothetical protein ColabFold model – – No map 0.024 0.32 No Hit 0.0% —
4796 VK055_1949 ykfE inhibitor of vertebrate C-type lysozyme ykfE AlphaFold DB model + ColabFold model –
GO:0043086Any process that stops or reduces the activity of an enzyme. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.024 0.266 No Hit 0.0% —
4797 VK055_1438 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.024 0.63 No Hit 0.0% —
4798 VK055_0042 putative ferritin-1 AlphaFold DB model + ColabFold model
1.16.3.2
GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008199Binding to a ferric iron ion, Fe(III). GO:0006879A homeostatic process involved in the maintenance of a steady state level of iron ions within a cell. +47 total
No map 0.024 0.587 No Hit 0.0% —
4799 VK055_5107 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.023 0.345 No Hit 0.0% —
4800 VK055_3747 ribosomal protein S12 rpsL AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +36 total
No map 0.023 0.171 Hit 48.2% 1.22e-28
Page of 204 · 5081 total proteins