Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 / 5081 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4801 VK055_2417 type II secretion system (T2SS), M family protein AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.023 0.361 No Hit 0.0% —
4802 VK055_2250 ethanolamine ammonia-lyase light chain family protein AlphaFold DB model + ColabFold model
4.3.1.7
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0009350An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. +36 total
No map 0.023 0.482 No Hit 0.0% —
4803 VK055_1601 potI potI AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.023 0.931 No Hit 0.0% —
4804 VK055_1214 acyl-CoA thioesterase yciA AlphaFold DB model + ColabFold model –
GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0052816Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. +25 total
Mapped 19 0.023 0.261 Hit 31.0% 1.42e-09
4805 VK055_0741 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.023 0.69 No Hit 0.0% —
4806 VK055_0689 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.023 0.712 No Hit 0.0% —
4807 VK055_0677 coenzyme PQQ biosynthesis protein PqqD pqqD AlphaFold DB model + ColabFold model –
GO:0018189The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.
No map 0.023 0.42 No Hit 0.0% —
4808 VK055_0449 transcriptional regulator, LuxR family AlphaFold DB model + ColabFold model – – No map 0.023 0.632 No Hit 0.0% —
4809 VK055_3611 universal stress B family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.022 0.696 No Hit 0.0% —
4810 VK055_3172 uroporphyrinogen-III synthase HemD family protein AlphaFold DB model + ColabFold model
4.2.1.75
GO:0006780The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0004852Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III. +14 total
No map 0.022 0.575 No Hit 0.0% —
4811 VK055_3090 heavy-metal resistance family protein AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.022 0.038 No Hit 0.0% —
4812 VK055_2709 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.022 0.575 No Hit 0.0% —
4813 VK055_2220 nonspecific DNA binding protein; nucleoid component rdgC AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.022 0.463 No Hit 0.0% —
4814 VK055_1116 opgC family protein ColabFold model – – No map 0.022 0.339 No Hit 0.0% —
4815 VK055_0709 ASCH domain protein ColabFold model – – No map 0.022 0.038 No Hit 0.0% —
4816 VK055_0571 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.022 0.289 No Hit 0.0% —
4817 VK055_0507 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.022 0.856 No Hit 0.0% —
4818 VK055_0110 stress, member of the CspA stress protein, member of the CspA family predicted DNA-binding transcriptional regulator cspC AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.022 0.276 Hit 63.3% 1.20e-07
4819 VK055_0011 hypothetical protein ColabFold model – – No map 0.022 0.533 No Hit 0.0% —
4820 VK055_4995 transcriptional regulatory, C terminal family protein AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +58 total
No map 0.021 0.076 No Hit 0.0% —
4821 VK055_4966 hypothetical protein Experimental + AlphaFold DB model + ColabFold model – – No map 0.021 0.479 No Hit 0.0% —
4822 VK055_4918 elongation factor P (EF-P) OB domain protein AlphaFold DB model + ColabFold model –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0043043The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map N/A 0.021 No Hit 0.0% —
4823 VK055_4792 smr domain protein AlphaFold DB model + ColabFold model
3.1.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks. GO:0019843Binding to a ribosomal RNA. +14 total
No map 0.021 0.211 No Hit 0.0% —
4824 VK055_4524 transcription activator HlyU AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.021 0.684 No Hit 0.0% —
4825 VK055_4436 periplasmic solute binding family protein AlphaFold DB model + ColabFold model –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0046872Binding to a metal ion. +14 total
No map 0.021 0.356 No Hit 0.0% —
Page of 204 · 5081 total proteins