Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
51 VK055_0381 CRISPR type I-E/ECOLI-associated protein CasB/Cse2 casB AlphaFold DB model + ColabFold model – – No map 0.017 No Hit 0.0% —
52 VK055_3111 ribosomal protein L7/L12 rplL AlphaFold DB model + ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +25 total
No map 0.017 Hit 38.7% 7.16e-06
53 VK055_0743 acetyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.018 No Hit 0.0% —
54 VK055_3019 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.018 No Hit 0.0% —
55 VK055_0733 putative transposase AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676Binding to a nucleic acid.
No map 0.019 No Hit 0.0% —
56 VK055_1003 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.019 No Hit 0.0% —
57 VK055_1910 putative transposase AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676Binding to a nucleic acid.
No map 0.019 No Hit 0.0% —
58 VK055_1989 putative transposase AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676Binding to a nucleic acid.
No map 0.019 No Hit 0.0% —
59 VK055_2272 putative transposase AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676Binding to a nucleic acid.
No map 0.019 No Hit 0.0% —
60 VK055_2785 putative transposase AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676Binding to a nucleic acid.
No map 0.019 No Hit 0.0% —
61 VK055_4147 putative transposase AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003676Binding to a nucleic acid.
No map 0.019 No Hit 0.0% —
62 VK055_4666 guaA GMP synthetase guaA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003921Catalysis of the reaction: ATP + XMP + NH4+ = AMP + diphosphate + GMP + 2H+. GO:0006177The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. +25 total
Mapped 3 0.019 Hit 36.5% 2.23e-93
63 VK055_0525 metal-sensitive transcriptional repressor familyprotein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0046872Binding to a metal ion. +14 total
No map 0.02 No Hit 0.0% —
64 VK055_5127 CP4-like integrase int2 AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.02 No Hit 0.0% —
65 VK055_2849 methionine sulfoxide reductase A msrA AlphaFold DB model + ColabFold model
1.8.4.11
GO:0008113Catalysis of the reaction: L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0033744Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol. +14 total
No map 0.021 Hit 70.7% 3.01e-41
66 VK055_4918 elongation factor P (EF-P) OB domain protein AlphaFold DB model + ColabFold model –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0043043The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
No map 0.021 No Hit 0.0% —
67 VK055_0609 muconolactone delta-isomerase catC AlphaFold DB model + ColabFold model
5.3.3.4
GO:0006725OBSOLETE. The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. GO:0016159Catalysis of the reaction: (S)-muconolactone = (4,5-dihydro-5-oxofuran-2-yl)-acetate. GO:0042952A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates.
Chokepoint 2 0.022 No Hit 0.0% —
68 VK055_1132 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.025 No Hit 0.0% —
69 VK055_4181 papC C-terminal domain protein ColabFold model – – No map 0.025 No Hit 0.0% —
70 VK055_1876 transcription antiterminator and regulator of RNA stability cspE AlphaFold DB model + ColabFold model –
GO:0003676Binding to a nucleic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.026 Hit 60.0% 6.40e-07
71 VK055_4521 hypothetical protein ColabFold model – – No map 0.026 No Hit 0.0% —
72 VK055_3124 UDP-N-acetylenolpyruvoylglucosamine reductase murB AlphaFold DB model + ColabFold model
1.3.1.98
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0008762Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +58 total
Chokepoint 1 0.027 No Hit 0.0% —
73 VK055_3428 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.027 No Hit 0.0% —
74 VK055_4158 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.027 No Hit 0.0% —
75 VK055_4672 addiction module antidote protein, HigA family higA ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.027 No Hit 0.0% —
Page of 204 · 5081 total proteins