Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
751 VK055_0532 alpha/beta hydrolase fold family protein AlphaFold DB model + ColabFold model
3.1.1.-
GO:0004104Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.
No map 0.926 0.932 Hit 58.0% 2.28e-13
752 VK055_0470 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.926 No Hit 0.0% —
753 VK055_0395 ccmC ccmC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. GO:0015232Enables the transfer of heme from one side of a membrane to the other. +36 total
No map 0.926 0.877 No Hit 0.0% —
754 VK055_0196 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.926 No Hit 0.0% —
755 VK055_4038 1-acylglycerol-3-phosphate O-acyltransferases domain protein AlphaFold DB model + ColabFold model
2.3.1.51
GO:0003841Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. +47 total
Mapped 2 0.925 0.901 Hit 29.9% 1.26e-32
756 VK055_2951 poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD pgaD AlphaFold DB model + ColabFold model –
GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
No map N/A 0.925 No Hit 0.0% —
757 VK055_2065 cysteine--tRNA ligase cysS AlphaFold DB model + ColabFold model
6.1.1.16
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004817Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +69 total
Chokepoint 2 0.925 0.222 Hit 56.0% 1.66e-25
758 VK055_1452 short chain dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.925 0.88 Hit 47.8% 4.16e-07
759 VK055_4952 acetyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.924 0.383 No Hit 0.0% —
760 VK055_4678 anaerobic sulfatase maturase AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +25 total
Mapped 1 0.924 0.611 No Hit 0.0% —
761 VK055_4042 2,5-diketo-D-gluconic acid reductase A dkgA AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
Mapped 1 0.924 0.157 Hit 47.2% 4.62e-12
762 VK055_3880 octaprenyl-diphosphate synthase ispB AlphaFold DB model + ColabFold model –
GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
Chokepoint 1 0.924 0.903 Hit 31.0% 8.67e-42
763 VK055_2839 fructose-1-6-bisphosphatase family protein AlphaFold DB model + ColabFold model
3.1.3.11
GO:0042578Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +811 total
No map 0.924 0.227 Hit 48.9% 1.20e-31
764 VK055_2812 PTS system, trehalose-specific IIBC component treP AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015574Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. +58 total
No map 0.924 0.496 No Hit 0.0% —
765 VK055_2675 putative CoA-substrate-specific enzyme activase domain protein AlphaFold DB model + ColabFold model –
GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. GO:0046872Binding to a metal ion.
No map 0.924 0.136 No Hit 0.0% —
766 VK055_2358 proline--tRNA ligase proS AlphaFold DB model + ColabFold model
6.1.1.15
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006433The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA. +69 total
Chokepoint 3 0.924 0.725 Hit 45.6% 6.86e-64
767 VK055_2219 glucokinase family protein AlphaFold DB model + ColabFold model –
GO:0004396Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
No map 0.924 0.366 Hit 25.3% 4.04e-10
768 VK055_1945 glycerol kinase glpK AlphaFold DB model + ColabFold model –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +47 total
Mapped 1 0.924 0.694 Hit 34.7% 8.86e-85
769 VK055_1315 antibiotic biosynthesis monooxygenase family protein AlphaFold DB model + ColabFold model –
GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water.
No map 0.924 0.865 No Hit 0.0% —
770 VK055_0661 bacterial alpha-L-rhamnosidase family protein AlphaFold DB model + ColabFold model
3.2.1.40
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0030596Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.
No map 0.924 0.886 No Hit 0.0% —
771 VK055_5027 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase manC AlphaFold DB model + ColabFold model
2.7.7.13
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0005976The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). +58 total
Chokepoint 3 0.923 0.103 No Hit 0.0% —
772 VK055_4469 pyridine nucleotide-disulfide oxidoreductase family protein AlphaFold DB model + ColabFold model
1.18.1.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016731Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.923 0.902 Hit 33.1% 1.13e-09
773 VK055_4419 phenolic acid decarboxylase subunit C bsdC AlphaFold DB model + ColabFold model
4.1.1.-
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008694Catalysis of the reaction: a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + H+ = a 2-(all-trans-polyprenyl)phenol + CO2. +36 total
Chokepoint 4 0.923 0.778 No Hit 0.0% —
774 VK055_3435 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
No map 0.923 0.648 No Hit 0.0% —
775 VK055_3067 short chain dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +14 total
No map 0.923 0.738 Hit 34.6% 3.12e-10
Page of 204 · 5081 total proteins