Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
801 VK055_2966 phosphonate metabolism transcriptional regulatorPhnF phnF AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.920 0.099 No Hit 0.0% —
802 VK055_2871 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.920 0.674 No Hit 0.0% —
803 VK055_2617 4-hydroxybenzoate 3-monooxygenase pobA AlphaFold DB model + ColabFold model
1.14.13.2
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0018659Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O. +14 total
Mapped 1 0.920 0.611 No Hit 0.0% —
804 VK055_2345 4-nitrobenzaldehyde reductase (multifunctional) AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:1990002Catalysis of the reaction: hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH. +14 total
Mapped 1 0.920 0.46 Hit 45.5% 2.99e-10
805 VK055_1123 response regulator AlphaFold DB model + ColabFold model
2.7.13.3
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0005515Binding to a protein. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. +58 total
No map 0.920 0.75 No Hit 0.0% —
806 VK055_0913 mannitol dehydrogenase Rossmann domain protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019594The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No map 0.920 0.809 No Hit 0.0% —
807 VK055_0639 metallo-beta-lactamase superfamily protein AlphaFold DB model + ColabFold model – – No map 0.920 0.812 No Hit 0.0% —
808 VK055_0424 NMT1/THI5 like family protein AlphaFold DB model + ColabFold model –
GO:0009228The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
No map 0.920 0.3 No Hit 0.0% —
809 VK055_4888 alkB repair system for alkylated DNA and RNA AlphaFold DB model + ColabFold model
1.14.11.33
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0035516Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA. GO:0008198Binding to a ferrous iron ion, Fe(II). +36 total
No map 0.919 0.856 Hit 32.5% 8.74e-14
810 VK055_4566 cytochrome C assembly family protein AlphaFold DB model + ColabFold model –
GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. GO:0020037Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.919 0.88 No Hit 0.0% —
811 VK055_4415 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.919 0.49 No Hit 0.0% —
812 VK055_4251 sdaC serine STP transporter sdaC2 AlphaFold DB model + ColabFold model –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.919 0.708 No Hit 0.0% —
813 VK055_4041 acetyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.919 0.885 No Hit 0.0% —
814 VK055_3741 slyX family protein AlphaFold DB model + ColabFold model – – No map N/A 0.919 No Hit 0.0% —
815 VK055_3598 putative transcriptional regulator LYSR-type AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
No map 0.919 0.722 No Hit 0.0% —
816 VK055_3100 thiazole biosynthesis adenylyltransferase ThiF thiF AlphaFold DB model + ColabFold model –
GO:0008641Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
Chokepoint 1 0.919 0.159 Hit 41.0% 5.49e-42
817 VK055_2143 pyridoxal-phosphate dependent enzyme family protein AlphaFold DB model + ColabFold model
4.4.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004124Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. +25 total
No map 0.919 0.859 Hit 23.7% 3.85e-15
818 VK055_1544 DNA internalization-related competence protein ComEC/Rec2 AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0030420The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.919 0.999 No Hit 0.0% —
819 VK055_1135 hypothetical protein ColabFold model – – No map N/A 0.919 No Hit 0.0% —
820 VK055_0663 lamB porin family protein AlphaFold DB model + ColabFold model –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034219The process in which a carbohydrate is transported across a membrane.
No map 0.919 0.725 No Hit 0.0% —
821 VK055_0161 tdcB tdcB AlphaFold DB model + ColabFold model
4.3.1.17
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. +47 total
No map 0.919 0.264 Hit 47.5% 9.61e-15
822 VK055_4666 guaA GMP synthetase guaA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003921Catalysis of the reaction: ATP + XMP + NH4+ = AMP + diphosphate + GMP + 2H+. GO:0006177The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. +25 total
Mapped 3 0.918 0.019 Hit 36.5% 2.23e-93
823 VK055_2179 tRNA sulfurtransferase ThiI thiI AlphaFold DB model + ColabFold model
2.8.1.4
GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0004810Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate. GO:0034227The addition a sulfur atom to a nucleotide in a tRNA molecule. +912 total
No map 0.918 0.958 No Hit 0.0% —
824 VK055_1548 3-phosphoshikimate 1-carboxyvinyltransferase aroA Experimental + ColabFold model
2.5.1.19
GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
Chokepoint 1 0.918 0.506 No Hit 0.0% —
825 VK055_4528 aldehyde dehydrogenase family protein AlphaFold DB model + ColabFold model
1.2.1.- 1.2.1.48
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050061Catalysis of the reaction: a long-chain fatty aldehyde + H2O + NAD+ = a long-chain fatty acid + 2 H+ + NADH.
No map 0.917 0.96 Hit 45.3% 1.29e-54
Page of 204 · 5081 total proteins