Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
776 VK055_3901 transcription termination/antitermination L factor nusA AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0031554Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. GO:0031564A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions. +69 total
0.886 No Hit 0.0% —
777 VK055_3421 eamA-like transporter family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.886 No Hit 0.0% —
778 VK055_2475 ddlB ddlB AlphaFold + ColabFold
6.3.2.4
GO:0008716Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H+ + phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
0.886 No Hit 0.0% —
779 VK055_2332 hydrolase AlphaFold + ColabFold
3.5.1.3
GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0106008Catalysis of the reaction: 2-oxoglutaramate + H2O = 2-oxoglutarate + NH3. GO:0050152Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH4+. Substrates include 2-oxosuccinamate and 2-oxoglutaramate, which get converted to oxaloacetate and 2-oxoglutarate, respectively.
0.886 Hit 30.8% 3.22e-07
780 VK055_2207 amidohydrolase family protein AlphaFold + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.886 No Hit 0.0% —
781 VK055_2138 amtB ammonium Amt transporter AmtB amtB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0072488The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. GO:0008519Enables the energy-independent facilitated diffusion of ammonium through a transmembrane aqueous pore or channel. +14 total
0.886 No Hit 0.0% —
782 VK055_1957 N-terminal TM domain of oligopeptide transport permease C family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.886 No Hit 0.0% —
783 VK055_1693 23S rRNA m6A1618 methyltransferase rlmF AlphaFold + ColabFold –
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0008988Catalysis of the reaction: adenosine in rRNA + S-adenosyl-L-methionine = H+ + N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +14 total
0.886 Hit 34.4% 4.71e-09
784 VK055_0661 bacterial alpha-L-rhamnosidase family protein AlphaFold + ColabFold
3.2.1.40
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0030596Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.
0.886 No Hit 0.0% —
785 VK055_5125 major Facilitator Superfamily protein ybtX AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.885 Hit 27.9% 4.99e-06
786 VK055_4041 acetyltransferase family protein AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.885 No Hit 0.0% —
787 VK055_0992 hypothetical protein AlphaFold + ColabFold – – 0.885 No Hit 0.0% —
788 VK055_0603 nitrate reductase, alpha subunit AlphaFold + ColabFold
1.7.5.1
GO:0042126The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043546Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. +811 total
0.885 No Hit 0.0% —
789 VK055_1421 hypothetical protein AlphaFold + ColabFold – – 0.884 No Hit 0.0% —
790 VK055_1377 fatty acid/phospholipid synthesis protein PlsX plsX AlphaFold + ColabFold
2.3.1.274
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). +36 total
0.884 No Hit 0.0% —
791 VK055_1240 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.884 No Hit 0.0% —
792 VK055_2472 cell division protein FtsZ ftsZ Experimental + ColabFold –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
0.883 No Hit 0.0% —
793 VK055_0286 citrate transporter family protein AlphaFold + ColabFold – – 0.883 No Hit 0.0% —
794 VK055_4250 putative oxidoreductase, NAD(P)-binding protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.882 Hit 24.2% 8.04e-10
795 VK055_2685 branched-chain amino acid transport system / permease component family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.882 No Hit 0.0% —
796 VK055_2029 hlyD secretion family protein AlphaFold + ColabFold – – 0.882 No Hit 0.0% —
797 VK055_0170 putative transcriptional regulator LYSR-type AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.882 No Hit 0.0% —
798 VK055_5032 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. +14 total
0.881 Hit 33.8% 1.62e-26
799 VK055_4776 histidine kinase-, DNA gyrase B-, and HSP90-likeATPase family protein AlphaFold + ColabFold
2.7.13.3
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0000155Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. +47 total
0.881 No Hit 0.0% —
800 VK055_3315 H+ antiporter-2 family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.881 No Hit 0.0% —
Page of 204 · 5081 total proteins