Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2501 KP13_01231 Regulator of cell morphogenesis and NO signaling AlphaFold + ColabFold –
GO:0030091The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. +25 total
No map 0.57 No Hit 0.0% —
2502 KP13_02903 putative S-adenosyl-L-methionine dependent methyltransferase AlphaFold + ColabFold –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
No map 0.569 No Hit 0.0% —
2503 KP13_00971 putative transposase AlphaFold + ColabFold –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.569 No Hit 0.0% —
2504 KP13_00783 Protein smg smg AlphaFold + ColabFold – – No map 0.569 No Hit 0.0% —
2505 KP13_32214 putative lipoprotein AlphaFold + ColabFold – – No map 0.568 No Hit 0.0% —
2506 KP13_06736 conjugal transfer TrbI-like protein trbI AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.568 No Hit 0.0% —
2507 KP13_05264 L-lactate dehydrogenase 2 ldh2 AlphaFold + ColabFold
1.1.1.27
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
No map 0.568 Hit 34.4% 2.64e-36
2508 KP13_04104 DNA-binding protein stpA stpA AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
No map 0.568 No Hit 0.0% —
2509 KP13_03555 Protein cysZ cysZ AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000103The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. GO:0015116Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. +25 total
No map 0.568 No Hit 0.0% —
2510 KP13_03174 hypothetical protein AlphaFold + ColabFold – – No map 0.568 No Hit 0.0% —
2511 KP13_00824 hypothetical protein AlphaFold + ColabFold – – No map 0.568 No Hit 0.0% —
2512 KP13_00697 Penicillin-binding protein 1A mrcA AlphaFold + ColabFold
2.4.99.28 3.4.16.4
GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
No map 0.568 No Hit 0.0% —
2513 KP13_06660 Histone-like nucleoid-structuring protein H-NS AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.567 No Hit 0.0% —
2514 KP13_03987 Conjugal transfer protein TrhY AlphaFold + ColabFold – – No map 0.567 No Hit 0.0% —
2515 KP13_01972 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase fkpB AlphaFold + ColabFold
5.2.1.8
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
No map 0.567 Hit 35.0% 1.38e-06
2516 KP13_10598 Peptidase B pepB AlphaFold + ColabFold
3.4.11.23
GO:0030145Binding to a manganese ion (Mn). GO:0019538The chemical reactions and pathways involving a protein. Includes protein modification. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
No map 0.566 Hit 40.2% 2.69e-18
2517 KP13_06620 hypothetical protein AlphaFold + ColabFold – – No map 0.566 No Hit 0.0% —
2518 KP13_03915 putative malonic semialdehyde reductase RutE rutE AlphaFold + ColabFold
1.1.1.298
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0035527Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH. GO:0019740A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. +14 total
No map 0.566 No Hit 0.0% —
2519 KP13_03873 Cell division inhibitor sulA sulA AlphaFold + ColabFold –
GO:0009432An error-prone process for repairing damaged microbial DNA. GO:0051782Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. GO:0000917The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. +14 total
No map 0.566 No Hit 0.0% —
2520 KP13_03762 Inner membrane transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map 0.566 Hit 26.9% 1.26e-09
2521 KP13_03112 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.566 No Hit 0.0% —
2522 KP13_02455 LuxR family transcriptional regulatory protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.566 No Hit 0.0% —
2523 KP13_00984 NADH-quinone oxidoreductase subunit K nuoK AlphaFold + ColabFold
7.1.1.-
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0030964An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. +36 total
No map 0.566 No Hit 0.0% —
2524 KP13_00320 Nickel transport system permease protein nikB nikB AlphaFold + ColabFold –
GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.566 No Hit 0.0% —
2525 KP13_31797 hypothetical protein AlphaFold + ColabFold – – No map 0.565 No Hit 0.0% —
Page of 208 · 5192 total proteins