Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2551 KP13_05029 hypothetical protein AlphaFold + ColabFold – – 0.606 No Hit 0.0% —
2552 KP13_02822 putative O-sialoglycoprotein endopeptidase gcp AlphaFold + ColabFold
2.3.1.234
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005506Binding to an iron (Fe) ion. +14 total
0.606 Hit 42.4% 3.35e-14
2553 KP13_02450 Class II aldolase/adducin domain-containing protein AlphaFold + ColabFold –
GO:0005856A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. GO:0051015Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.
0.606 Hit 47.1% 3.53e-15
2554 KP13_01490 Sulphatase-modifying factor domain-containing protein AlphaFold + ColabFold – – 0.606 Hit 36.9% 1.11e-06
2555 KP13_31771 Zinc-type alcohol dehydrogenase-like protein AlphaFold + ColabFold
1.1.1.2
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +14 total
0.605 Hit 30.8% 2.75e-07
2556 KP13_05610 Inner membrane transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.605 No Hit 0.0% —
2557 KP13_04464 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.605 Hit 57.5% 3.25e-07
2558 KP13_02879 hypothetical protein AlphaFold + ColabFold –
GO:0043022Binding to a ribosome. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.605 No Hit 0.0% —
2559 KP13_01566 M22 peptidase-like protein AlphaFold + ColabFold –
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.605 No Hit 0.0% —
2560 KP13_01512 hypothetical protein AlphaFold + ColabFold – – 0.605 No Hit 0.0% —
2561 KP13_04145 Tellurium resistance protein terA terA AlphaFold + ColabFold – – 0.604 No Hit 0.0% —
2562 KP13_03154 putative protease AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +14 total
0.604 No Hit 0.0% —
2563 KP13_02315 Propanediol dehydratase small subunit pduE AlphaFold + ColabFold – – 0.604 No Hit 0.0% —
2564 KP13_01454 Replication protein repA repA AlphaFold + ColabFold –
GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0006270The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
0.604 No Hit 0.0% —
2565 KP13_00867 putative oxidoreductase AlphaFold + ColabFold – – 0.604 No Hit 0.0% —
2566 KP13_00058 D-galactonate dehydratase dgoD AlphaFold + ColabFold
4.2.1.6
GO:0008869Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O. GO:0034194The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid. GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. +14 total
0.604 Hit 25.8% 4.31e-10
2567 KP13_32171 hypothetical protein ColabFold – – 0.603 No Hit 0.0% —
2568 KP13_03458 hypothetical protein ColabFold – – 0.603 No Hit 0.0% —
2569 KP13_01545 Ferrioxamine receptor AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +25 total
0.603 No Hit 0.0% —
2570 KP13_01309 hypothetical protein AlphaFold + ColabFold – – 0.603 No Hit 0.0% —
2571 KP13_01115 GTPase obg obg AlphaFold + ColabFold
3.6.5.-
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0000287Binding to a magnesium (Mg) ion. +47 total
0.603 Hit 44.2% 5.00e-17
2572 KP13_05453 hypothetical protein AlphaFold + ColabFold – – 0.602 No Hit 0.0% —
2573 KP13_05116 Oligopeptide ABC transport system oligopeptide-binding component AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
0.602 No Hit 0.0% —
2574 KP13_04726 putative aromatic amino acid transporter AlphaFold + ColabFold –
GO:0003333The process in which an amino acid is transported across a membrane. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.602 No Hit 0.0% —
2575 KP13_04355 hypothetical protein ColabFold – – 0.602 No Hit 0.0% —
Page of 234 · 5842 total proteins