Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2776 KP13_00783 Protein smg smg AlphaFold + ColabFold – – 0.569 No Hit 0.0% —
2777 KP13_32214 putative lipoprotein AlphaFold + ColabFold – – 0.568 No Hit 0.0% —
2778 KP13_32090 hypothetical protein ColabFold – – 0.568 No Hit 0.0% —
2779 KP13_06736 conjugal transfer TrbI-like protein trbI AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.568 No Hit 0.0% —
2780 KP13_05264 L-lactate dehydrogenase 2 ldh2 AlphaFold + ColabFold
1.1.1.27
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
0.568 Hit 34.4% 2.64e-36
2781 KP13_04104 DNA-binding protein stpA stpA AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
0.568 No Hit 0.0% —
2782 KP13_03555 Protein cysZ cysZ AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0000103The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. GO:0015116Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. +25 total
0.568 No Hit 0.0% —
2783 KP13_03174 hypothetical protein AlphaFold + ColabFold – – 0.568 No Hit 0.0% —
2784 KP13_00824 hypothetical protein AlphaFold + ColabFold – – 0.568 No Hit 0.0% —
2785 KP13_00697 Penicillin-binding protein 1A mrcA AlphaFold + ColabFold
2.4.99.28 3.4.16.4
GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
0.568 No Hit 0.0% —
2786 KP13_06660 Histone-like nucleoid-structuring protein H-NS AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.567 No Hit 0.0% —
2787 KP13_04080 hypothetical protein ColabFold – – 0.567 No Hit 0.0% —
2788 KP13_03987 Conjugal transfer protein TrhY AlphaFold + ColabFold – – 0.567 No Hit 0.0% —
2789 KP13_01972 FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase fkpB AlphaFold + ColabFold
5.2.1.8
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
0.567 Hit 35.0% 1.38e-06
2790 KP13_10598 Peptidase B pepB AlphaFold + ColabFold
3.4.11.23
GO:0030145Binding to a manganese ion (Mn). GO:0019538The chemical reactions and pathways involving a protein. Includes protein modification. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.566 Hit 40.2% 2.69e-18
2791 KP13_06620 hypothetical protein AlphaFold + ColabFold – – 0.566 No Hit 0.0% —
2792 KP13_03915 putative malonic semialdehyde reductase RutE rutE AlphaFold + ColabFold
1.1.1.298
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0035527Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH. GO:0019740A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. +14 total
0.566 No Hit 0.0% —
2793 KP13_03873 Cell division inhibitor sulA sulA AlphaFold + ColabFold –
GO:0009432An error-prone process for repairing damaged microbial DNA. GO:0051782Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. GO:0000917The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. +14 total
0.566 No Hit 0.0% —
2794 KP13_03762 Inner membrane transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.566 Hit 26.9% 1.26e-09
2795 KP13_03112 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
0.566 No Hit 0.0% —
2796 KP13_02455 LuxR family transcriptional regulatory protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.566 No Hit 0.0% —
2797 KP13_01749 AraC family transcriptional regulator ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.566 No Hit 0.0% —
2798 KP13_00984 NADH-quinone oxidoreductase subunit K nuoK AlphaFold + ColabFold
7.1.1.-
GO:0042773The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0030964An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. +36 total
0.566 No Hit 0.0% —
2799 KP13_00320 Nickel transport system permease protein nikB nikB AlphaFold + ColabFold –
GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.566 No Hit 0.0% —
2800 KP13_31797 hypothetical protein AlphaFold + ColabFold – – 0.565 No Hit 0.0% —
Page of 234 · 5842 total proteins