Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
301 KP13_04384 Zinc transport protein zntB zntB AlphaFold + ColabFold –
GO:0005385Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071577A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. +811 total
0.961 No Hit 0.0% —
302 KP13_02179 Glycine dehydrogenase gcvP AlphaFold + ColabFold
1.4.4.2
GO:0006546The chemical reactions and pathways resulting in the breakdown of glycine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006544The chemical reactions and pathways involving glycine, aminoethanoic acid. +69 total
0.961 Hit 67.3% 2.72e-20
303 KP13_01671 hypothetical protein AlphaFold + ColabFold – – 0.961 No Hit 0.0% —
304 KP13_01238 hypothetical protein AlphaFold + ColabFold – – 0.961 No Hit 0.0% —
305 KP13_05206 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.96 No Hit 0.0% —
306 KP13_05193 putative fucose permease AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0015535Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in). GO:0015756The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. +36 total
0.96 No Hit 0.0% —
307 KP13_04701 DNA-binding protein H-NS AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
0.96 No Hit 0.0% —
308 KP13_04683 kinase-like domain-containing protein AlphaFold + ColabFold – – 0.96 Hit 43.4% 1.29e-14
309 KP13_04095 Aldehyde dehydrogenase aldA AlphaFold + ColabFold
1.2.1.- 1.2.1.48
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0050061Catalysis of the reaction: a long-chain fatty aldehyde + H2O + NAD+ = a long-chain fatty acid + 2 H+ + NADH.
0.96 Hit 45.3% 1.22e-54
310 KP13_03308 OprD-like protein oprD AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0046930A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. +47 total
0.96 No Hit 0.0% —
311 KP13_03147 C4-dicarboxylate transport protein AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.96 Hit 35.9% 3.81e-07
312 KP13_02104 putative acyltransferase AlphaFold + ColabFold
2.3.2.30
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0043810Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
0.96 No Hit 0.0% —
313 KP13_05070 hypothetical protein AlphaFold + ColabFold – – 0.959 No Hit 0.0% —
314 KP13_02248 hypothetical protein AlphaFold + ColabFold – – 0.959 No Hit 0.0% —
315 KP13_01918 Acetolactate synthase isozyme 3 large subunit ilvI AlphaFold + ColabFold
2.2.1.6
GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0003984Catalysis of the reaction: H+ + 2 pyruvate = (2S)-2-acetolactate + CO2. Can also convert 2-oxobutanoate and pyruvate to (S)-2-ethyl-2-hydroxy-3-oxobutanoate. GO:0000287Binding to a magnesium (Mg) ion. +69 total
0.959 Hit 41.7% 3.34e-19
316 KP13_31761 biotin sulfoxide reductase bisC AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043546Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +36 total
0.958 No Hit 0.0% —
317 KP13_03703 tRNA sulfurtransferase thiI AlphaFold + ColabFold
2.8.1.4
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0052837The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position. GO:0004810Catalysis of the reaction: a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate. +912 total
0.958 No Hit 0.0% —
318 KP13_03197 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.958 No Hit 0.0% —
319 KP13_02008 Trifunctional NAD biosynthesis/regulator protein NadR nadR AlphaFold + ColabFold
2.7.1.22 2.7.7.1
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0009435The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD+), a coenzyme that interconverts with its reduced form, NADH, in many redox and catabolic reactions. NAD+ is derived from various sources including vitamin B3. GO:0000309Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + ATP + H+ = diphosphate + NAD+. +69 total
0.958 No Hit 0.0% —
320 KP13_01342 5-methylcytosine restriction system component protein AlphaFold + ColabFold –
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
0.958 No Hit 0.0% —
321 KP13_00159 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.958 No Hit 0.0% —
322 KP13_31977 hypothetical protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.957 No Hit 0.0% —
323 KP13_04986 putative major facilitator superfamily permease AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.957 No Hit 0.0% —
324 KP13_04545 HTH-type DNA-binding domain-containing acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.957 Hit 30.2% 2.10e-06
325 KP13_02428 cystathionine beta-synthase domain-containing protein Experimental + AlphaFold + ColabFold –
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
0.957 Hit 25.9% 5.68e-16
Page of 208 · 5192 total proteins