Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3401 KP13_02354 L-fucose isomerase fucI AlphaFold + ColabFold
5.3.1.25
GO:0030145Binding to a manganese ion (Mn). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008736Catalysis of the reaction: L-fucose = L-fuculose. +710 total
0.48 No Hit 0.0% —
3402 KP13_02161 Fructose-bisphosphate aldolase class 2 fbaA AlphaFold + ColabFold
4.1.2.13
GO:0008270Binding to a zinc ion (Zn). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. +47 total
0.48 No Hit 0.0% —
3403 KP13_01649 hypothetical protein AlphaFold + ColabFold – – 0.48 No Hit 0.0% —
3404 KP13_00024 ATP synthase gamma chain atpG AlphaFold + ColabFold –
GO:0045261OBSOLETE. The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. GO:0015986The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0046933Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in). +47 total
0.48 Hit 30.2% 1.60e-27
3405 KP13_03180 hypothetical protein Experimental + AlphaFold + ColabFold – – 0.479 No Hit 0.0% —
3406 KP13_01241 Glycosyl hydrolase 42 family protein AlphaFold + ColabFold
3.2.1.23
GO:0004565Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0009341A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. +14 total
0.479 No Hit 0.0% —
3407 KP13_32405 hypothetical protein AlphaFold + ColabFold – – 0.478 No Hit 0.0% —
3408 KP13_31744 Formate dehydrogenase-O iron-sulfur subunit fdoH AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015944The chemical reactions and pathways by which formate is converted to CO2. GO:0045333The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). +69 total
0.478 No Hit 0.0% —
3409 KP13_01751 putative membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.478 No Hit 0.0% —
3410 KP13_01711 hypothetical protein AlphaFold + ColabFold – – 0.478 No Hit 0.0% —
3411 KP13_00894 hypothetical protein AlphaFold + ColabFold – – 0.478 No Hit 0.0% —
3412 KP13_00301 GCN5-related N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.478 No Hit 0.0% —
3413 KP13_00199 lipopolysaccharide core biosynthesis protein RfaZ rfaZ AlphaFold + ColabFold – – 0.478 No Hit 0.0% —
3414 KP13_32039 hypothetical protein ColabFold – – 0.477 No Hit 0.0% —
3415 KP13_12908 hypothetical protein AlphaFold + ColabFold – – 0.477 No Hit 0.0% —
3416 KP13_05360 putative hydroxypyruvate reductase ttuD AlphaFold + ColabFold –
GO:0008887Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.477 Hit 44.1% 1.01e-38
3417 KP13_04675 50S ribosomal protein L35 rpmI AlphaFold + ColabFold –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
0.477 No Hit 0.0% —
3418 KP13_02744 A/G-specific adenine glycosylase mutY AlphaFold + ColabFold
3.2.2.31
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016798Catalysis of the hydrolysis of any glycosyl bond. GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +1013 total
0.477 Hit 44.9% 2.75e-56
3419 KP13_01617 High-affinity zinc uptake system protein znuA znuA AlphaFold + ColabFold –
GO:0030001The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0046872Binding to a metal ion. GO:0006829The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.477 No Hit 0.0% —
3420 KP13_01595 Ribosomal RNA small subunit methyltransferase F rsmF AlphaFold + ColabFold
2.1.1.178
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. +69 total
0.477 Hit 39.2% 7.47e-26
3421 KP13_04617 hypothetical protein AlphaFold + ColabFold –
GO:0030973Binding to a molybdate ion (MoO4 2-). GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
0.476 No Hit 0.0% —
3422 KP13_04012 putative lysozyme from lambdoid prophage DLP12 arrD AlphaFold + ColabFold –
GO:0009253The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0003796Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. GO:0016998The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.
0.476 No Hit 0.0% —
3423 KP13_02970 Ribonuclease G rng AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0004540Catalysis of the cleavage of phosphodiester bonds in chains of RNA. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +14 total
0.476 No Hit 0.0% —
3424 KP13_00096 putative 2-aminoethylphosphonate import ATP-binding protein phnT phnT AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.476 Hit 43.3% 2.59e-07
3425 KP13_01389 Beta-lactamase OXA-9 bla AlphaFold + ColabFold
3.5.2.6
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. +14 total
0.475 No Hit 0.0% —
Page of 234 · 5842 total proteins