Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3376 KP13_31829 hypothetical protein AlphaFold + ColabFold – – 0.482 No Hit 0.0% —
3377 KP13_31825 hypothetical protein ColabFold – – 0.482 No Hit 0.0% —
3378 KP13_04979 Phenylacetic acid degradation protein paaY paaY AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.482 No Hit 0.0% —
3379 KP13_04875 Spermidine/putrescine transport system permease protein potC potC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.482 No Hit 0.0% —
3380 KP13_04221 Translation initiation factor IF-1 infA AlphaFold + ColabFold –
GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0006413The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
0.482 No Hit 0.0% —
3381 KP13_03882 phosphatidylethanolamine-binding protein AlphaFold + ColabFold – – 0.482 No Hit 0.0% —
3382 KP13_03879 NAD(P)-binding domain-containing protein Experimental + AlphaFold + ColabFold – – 0.482 No Hit 0.0% —
3383 KP13_02601 hypothetical protein AlphaFold + ColabFold – – 0.482 No Hit 0.0% —
3384 KP13_02271 6-phospho-beta-glucosidase gmuD gmuD AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.482 Hit 29.9% 4.29e-11
3385 KP13_02113 Ethanolamine ammonia-lyase light chain AlphaFold + ColabFold
4.3.1.7
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0009350An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. +36 total
0.482 No Hit 0.0% —
3386 KP13_00877 hypothetical protein ColabFold – – 0.482 No Hit 0.0% —
3387 KP13_00222 Mannitol-1-phosphate 5-dehydrogenase mtlD AlphaFold + ColabFold
1.1.1.17
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019594The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. +36 total
0.482 No Hit 0.0% —
3388 KP13_32010 hypothetical protein AlphaFold + ColabFold – – 0.481 No Hit 0.0% —
3389 KP13_31630 HNH nuclease domain-containing protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0008270Binding to a zinc ion (Zn). GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
0.481 No Hit 0.0% —
3390 KP13_05047 Fumarate hydratase class I, anaerobic fumB AlphaFold + ColabFold
4.2.1.2
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0004333Catalysis of the reaction: (S)-malate = fumarate + H2O. +58 total
0.481 No Hit 0.0% —
3391 KP13_04692 Oligopeptide transport ATP-binding protein oppF oppF AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.481 Hit 32.8% 2.25e-21
3392 KP13_02632 DNA replication protein dnaC dnaC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:1990077Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. +36 total
0.481 No Hit 0.0% —
3393 KP13_01966 hypothetical protein AlphaFold + ColabFold – – 0.481 No Hit 0.0% —
3394 KP13_01296 putative amidohydrolase AlphaFold + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.481 No Hit 0.0% —
3395 KP13_01131 putative epimerase/isomerase AlphaFold + ColabFold –
GO:0008903Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. GO:0046487The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH.
0.481 Hit 48.6% 1.47e-64
3396 KP13_01030 Flagellar regulator flk flk AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0010468Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
0.481 No Hit 0.0% —
3397 KP13_00576 Cell division protein ftsN ftsN AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. +36 total
0.481 No Hit 0.0% —
3398 KP13_31809 Dephospho-CoA kinase coaE AlphaFold + ColabFold
2.7.1.24
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004140Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H+. GO:0015937The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. +14 total
0.48 Hit 45.9% 7.74e-25
3399 KP13_05372 putative ferredoxin-like protein AlphaFold + ColabFold – – 0.48 No Hit 0.0% —
3400 KP13_04563 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.48 No Hit 0.0% —
Page of 234 · 5842 total proteins