Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

Search, filter, and prioritize proteins.

Export view
5842 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3526 KP13_02489 hypothetical protein AlphaFold + ColabFold – – 0.458 No Hit 0.0% —
3527 KP13_01909 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase murF AlphaFold + ColabFold –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0047480Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP. GO:0016881Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. +25 total
0.458 No Hit 0.0% —
3528 KP13_01539 Proteasome subunit alpha/beta domain-containing protein AlphaFold + ColabFold –
GO:0005839A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. GO:0051603OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
0.458 No Hit 0.0% —
3529 KP13_00861 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase ispG AlphaFold + ColabFold –
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0016114The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. GO:0005506Binding to an iron (Fe) ion. +25 total
0.458 No Hit 0.0% —
3530 KP13_05080 Acetoin(diacetyl) reductase budC Experimental + ColabFold
1.1.1.304
GO:0019152Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. This reaction is catalyzed in the reverse direction. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0045150The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone. +14 total
0.457 Hit 41.9% 7.64e-11
3531 KP13_04581 hypothetical protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.457 No Hit 0.0% —
3532 KP13_03509 putative periplasmic binding protein AlphaFold + ColabFold – – 0.457 No Hit 0.0% —
3533 KP13_02477 Sigma-54 dependent transcriptional regulator AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +47 total
0.457 No Hit 0.0% —
3534 KP13_01421 Transcriptional repressor protein korC korC AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.457 No Hit 0.0% —
3535 KP13_00860 Cytoskeleton protein rodZ rodZ AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008360Any process that modulates the surface configuration of a cell. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.457 No Hit 0.0% —
3536 KP13_00189 Phosphopantetheine adenylyltransferase coaD Experimental + ColabFold
2.7.7.3
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0015937The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.457 No Hit 0.0% —
3537 KP13_03812 Phosphoribosylformylglycinamidine cyclo-ligase purM AlphaFold + ColabFold –
GO:0004641Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H+ + phosphate. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
0.456 Hit 49.4% 1.41e-106
3538 KP13_01558 Fumarylacetoacetate hydrolase domain-containing protein AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0018773Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate. GO:0046872Binding to a metal ion.
0.456 Hit 46.0% 9.36e-62
3539 KP13_01206 Putative glycerophosphoryl diester phosphodiesterase AlphaFold + ColabFold
3.1.4.46
GO:0008081Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0008889Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.
0.456 Hit 37.9% 1.16e-07
3540 KP13_01186 Sensor protein dcuS dcuS AlphaFold + ColabFold –
GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). +25 total
0.456 No Hit 0.0% —
3541 KP13_01149 Universal stress protein G uspG AlphaFold + ColabFold – – 0.456 No Hit 0.0% —
3542 KP13_00736 hypothetical protein AlphaFold + ColabFold – – 0.456 No Hit 0.0% —
3543 KP13_05830 hypothetical protein AlphaFold + ColabFold – – 0.455 No Hit 0.0% —
3544 KP13_04615 putative ABC transporter permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.455 No Hit 0.0% —
3545 KP13_03107 putative plasmid partitioning protein, RepA AlphaFold + ColabFold – – 0.455 No Hit 0.0% —
3546 KP13_02972 Protein tldD tldD AlphaFold + ColabFold –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.455 No Hit 0.0% —
3547 KP13_01600 hypothetical protein AlphaFold + ColabFold – – 0.455 No Hit 0.0% —
3548 KP13_01571 putative Nudix hydrolase nudL nudL AlphaFold + ColabFold
3.6.1.-
GO:0030145Binding to a manganese ion (Mn). GO:0010945Catalysis of the reaction: an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + an acyl-4'-phosphopantetheine + 2 H+. This reaction can also use coenzyme A as a substrate. GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. +25 total
0.455 Hit 41.8% 2.03e-12
3549 KP13_01173 AI-2 transport protein tqsA tqsA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.455 No Hit 0.0% —
3550 KP13_00592 L-rhamnose isomerase rhaA AlphaFold + ColabFold
5.3.1.14
GO:0019299OBSOLETE. The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. GO:0030145Binding to a manganese ion (Mn). GO:0008740Catalysis of the reaction: L-rhamnose = L-rhamnulose. +36 total
0.455 No Hit 0.0% —
Page of 234 · 5842 total proteins