Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3576 KP13_32095 peptidase family S49 AlphaFold + ColabFold –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
0.451 No Hit 0.0% —
3577 KP13_06647 hypothetical protein ColabFold – – 0.451 No Hit 0.0% —
3578 KP13_06614 hypothetical protein ColabFold – – 0.451 No Hit 0.0% —
3579 KP13_03693 hypothetical protein AlphaFold + ColabFold – – 0.451 Hit 34.6% 1.17e-08
3580 KP13_03611 hypothetical protein ColabFold – – 0.451 No Hit 0.0% —
3581 KP13_03440 putative ABC transporter AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.451 Hit 58.8% 5.42e-06
3582 KP13_02649 hypothetical protein AlphaFold + ColabFold – – 0.451 No Hit 0.0% —
3583 KP13_02585 Electron transport protein hydN hydN AlphaFold + ColabFold –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
0.451 No Hit 0.0% —
3584 KP13_02317 Propanediol dehydratase large subunit pduC AlphaFold + ColabFold –
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0031419Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
0.451 No Hit 0.0% —
3585 KP13_01099 Ribosome-binding factor A rbfA AlphaFold + ColabFold –
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0043024Binding to a small ribosomal subunit. +14 total
0.451 No Hit 0.0% —
3586 KP13_00937 Putative aga operon transcriptional repressor agaR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.451 No Hit 0.0% —
3587 KP13_00651 Glycerophosphoryl diester phosphodiesterase ugpQ AlphaFold + ColabFold –
GO:0008081Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
0.451 Hit 41.2% 1.20e-14
3588 KP13_06790 Mobilization protein mbeC mbeC ColabFold – – 0.45 No Hit 0.0% —
3589 KP13_05660 Pyrazinamidase/nicotinamidase pncA AlphaFold + ColabFold
3.5.1.19
GO:0046872Binding to a metal ion. GO:0008936Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH4+. GO:0019363The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.
0.45 No Hit 0.0% —
3590 KP13_03013 putative Acriflavin resistance protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.45 No Hit 0.0% —
3591 KP13_02687 hypothetical protein AlphaFold + ColabFold – – 0.45 No Hit 0.0% —
3592 KP13_02440 Efflux pump OqxA oqxA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.45 No Hit 0.0% —
3593 KP13_00729 putative ABC transporter ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.45 Hit 42.7% 3.35e-22
3594 KP13_00701 hypothetical protein AlphaFold + ColabFold – – 0.45 No Hit 0.0% —
3595 KP13_00204 L-threonine 3-dehydrogenase tdh AlphaFold + ColabFold
1.1.1.103
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0006567The chemical reactions and pathways resulting in the breakdown of L-threonine. +36 total
0.45 Hit 32.4% 1.06e-08
3596 KP13_00117 N-acetylmuramic acid 6-phosphate etherase murQ AlphaFold + ColabFold
4.2.1.126
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0016835Catalysis of the breakage of a carbon-oxygen bond. GO:0046348The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. +58 total
0.45 Hit 23.3% 3.64e-07
3597 KP13_05657 hypothetical protein AlphaFold + ColabFold – – 0.449 No Hit 0.0% —
3598 KP13_05497 putative transmembrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.449 No Hit 0.0% —
3599 KP13_04861 Isocitrate dehydrogenase [NADP] icd AlphaFold + ColabFold
1.1.1.42
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0000287Binding to a magnesium (Mg) ion. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +36 total
0.449 Hit 40.7% 4.43e-08
3600 KP13_04265 hypothetical protein ColabFold – – 0.449 No Hit 0.0% —
Page of 234 · 5842 total proteins