Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3626 KP13_03228 Phosphocarrier protein NPr ptsO AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
0.444 No Hit 0.0% —
3627 KP13_03072 putative transmembrane protein ColabFold – – 0.444 No Hit 0.0% —
3628 KP13_01712 Tyrosine recombinase xerC xerC AlphaFold + ColabFold –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +58 total
0.444 No Hit 0.0% —
3629 KP13_00951 hypothetical protein ColabFold – – 0.444 No Hit 0.0% —
3630 KP13_00905 hypothetical protein AlphaFold + ColabFold – – 0.444 No Hit 0.0% —
3631 KP13_32151 hypothetical protein ColabFold – – 0.443 No Hit 0.0% —
3632 KP13_31777 hypothetical protein AlphaFold + ColabFold – – 0.443 No Hit 0.0% —
3633 KP13_03731 putative DNA processing protein AlphaFold + ColabFold – – 0.443 No Hit 0.0% —
3634 KP13_02404 hypothetical protein ColabFold – – 0.443 No Hit 0.0% —
3635 KP13_02126 hypothetical protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
0.443 No Hit 0.0% —
3636 KP13_01253 Inner membrane ABC transporter permease protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.443 No Hit 0.0% —
3637 KP13_00429 Fimbrial protein AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.443 No Hit 0.0% —
3638 KP13_31891 hypothetical protein ColabFold – – 0.442 No Hit 0.0% —
3639 KP13_04433 hypothetical protein AlphaFold + ColabFold – – 0.442 No Hit 0.0% —
3640 KP13_04203 hypothetical protein AlphaFold + ColabFold – – 0.442 No Hit 0.0% —
3641 KP13_03632 Biofilm formation regulator YbaJ-like protein AlphaFold + ColabFold – – 0.442 No Hit 0.0% —
3642 KP13_01931 Sugar efflux transporter A setA AlphaFold + ColabFold –
GO:0005351Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +69 total
0.442 No Hit 0.0% —
3643 KP13_01513 AIG2 family protein AlphaFold + ColabFold – – 0.442 No Hit 0.0% —
3644 KP13_01081 putative transporter protein AlphaFold + ColabFold – – 0.442 No Hit 0.0% —
3645 KP13_00653 Gamma-glutamyltranspeptidase ggt AlphaFold + ColabFold
2.3.2.2 3.4.19.13
GO:0006751The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. GO:0036374Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. GO:0103068OBSOLETE. Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. +14 total
0.442 Hit 40.9% 2.69e-24
3646 KP13_32128 maltose/maltodextrin import ATP-binding protein MalK AlphaFold + ColabFold –
GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +47 total
0.441 Hit 57.1% 1.11e-06
3647 KP13_02768 hypothetical protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.441 Hit 26.6% 8.92e-10
3648 KP13_02351 L-fucose operon activator fucR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.441 No Hit 0.0% —
3649 KP13_01943 L-arabinose isomerase araA AlphaFold + ColabFold
5.3.1.4
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0008733Catalysis of the reaction: L-arabinose = L-ribulose. +47 total
0.441 No Hit 0.0% —
3650 KP13_01531 Propionate kinase tdcD AlphaFold + ColabFold –
GO:0016774Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. +14 total
0.441 No Hit 0.0% —
Page of 234 · 5842 total proteins