Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3751 KP13_03730 putative transposase AlphaFold DB model + ColabFold model – – No map 0.074 No Hit 0.0% —
3752 KP13_03731 putative DNA processing protein AlphaFold DB model + ColabFold model – – No map 0.443 No Hit 0.0% —
3753 KP13_03732 Signal peptidase S49 AlphaFold DB model + ColabFold model
3.4.21.-
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
No map 0.313 No Hit 0.0% —
3754 KP13_03733 Conjugal transfer protein TraJ AlphaFold DB model + ColabFold model – – No map 0.686 No Hit 0.0% —
3755 KP13_03734 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.609 No Hit 0.0% —
3756 KP13_03737 hypothetical protein ColabFold model – – No map 0.18 No Hit 0.0% —
3757 KP13_03738 hypothetical protein ColabFold model – – No map 0.341 No Hit 0.0% —
3758 KP13_03739 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.14 No Hit 0.0% —
3759 KP13_03740 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.713 No Hit 0.0% —
3760 KP13_03741 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.499 No Hit 0.0% —
3761 KP13_03742 HTH-type transcriptional regulator cynR cynR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
No map 0.413 No Hit 0.0% —
3762 KP13_03744 Cyanate transport protein cynX cynX AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.939 No Hit 0.0% —
3763 KP13_03746 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0051213Catalysis of the incorporation of both atoms of molecular oxygen (O2) into the substrate.
No map 0.63 No Hit 0.0% —
3764 KP13_03747 Inner membrane protein AlphaFold DB model + ColabFold model
2.7.13.3
GO:0004673Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +47 total
No map 0.881 No Hit 0.0% —
3765 KP13_03748 putative response regulatory protein AlphaFold DB model + ColabFold model –
GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000156Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. +14 total
No map 0.256 No Hit 0.0% —
3766 KP13_03749 Glucokinase glk AlphaFold DB model + ColabFold model
2.7.1.2
GO:0004340Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005536Binding to D-enantiomers of glucose. +36 total
No map 0.743 No Hit 0.0% —
3767 KP13_03750 Putative ion-transport protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005247Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. GO:0006821The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +47 total
No map 0.815 No Hit 0.0% —
3768 KP13_03753 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.466 No Hit 0.0% —
3769 KP13_03755 hypothetical protein ColabFold model – – No map 0.735 No Hit 0.0% —
3770 KP13_03757 GGDEF domain-containing protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
No map 0.893 No Hit 0.0% —
3771 KP13_03758 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.199 No Hit 0.0% —
3772 KP13_03761 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.189 No Hit 0.0% —
3773 KP13_03763 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.908 No Hit 0.0% —
3774 KP13_03764 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.
No map 0.563 No Hit 0.0% —
3775 KP13_03765 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.768 No Hit 0.0% —
Page of 234 · 5842 total proteins