Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3801 KP13_04971 putative phenylacetic acid degradation NADH oxidoreductase paaE paaE AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0010124The chemical reactions and pathways resulting in the breakdown of phenylacetate. +36 total
0.352 Hit 26.7% 1.63e-09
3802 KP13_04779 hypothetical protein AlphaFold + ColabFold – – 0.352 No Hit 0.0% —
3803 KP13_02337 Cobalt transport protein cbiN cbiN AlphaFold + ColabFold –
GO:0006824The directed movement of cobalt (Co2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015087Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +25 total
0.352 No Hit 0.0% —
3804 KP13_02026 DNA polymerase III subunit psi holD AlphaFold + ColabFold –
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003887Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
0.352 No Hit 0.0% —
3805 KP13_00843 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ trmJ AlphaFold + ColabFold
2.1.1.200
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.352 No Hit 0.0% —
3806 KP13_00668 hypothetical protein AlphaFold + ColabFold – – 0.352 No Hit 0.0% —
3807 KP13_04676 Translation initiation factor IF-3 infC AlphaFold + ColabFold –
GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0006413The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.351 No Hit 0.0% —
3808 KP13_03766 hypothetical protein AlphaFold + ColabFold – – 0.351 No Hit 0.0% —
3809 KP13_02733 putative Holliday junction resolvase AlphaFold + ColabFold –
GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0006139Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
0.351 No Hit 0.0% —
3810 KP13_00495 hypothetical protein AlphaFold + ColabFold – – 0.351 No Hit 0.0% —
3811 KP13_05739 hypothetical protein AlphaFold + ColabFold – – 0.35 No Hit 0.0% —
3812 KP13_01377 hypothetical protein AlphaFold + ColabFold – – 0.35 No Hit 0.0% —
3813 KP13_00206 hypothetical protein AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.35 No Hit 0.0% —
3814 KP13_04715 Nitrate/nitrite response regulator protein narL narL AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.349 No Hit 0.0% —
3815 KP13_02700 Ketol-acid reductoisomerase ilvC AlphaFold + ColabFold
1.1.1.86
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004455Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. GO:0009082The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. +47 total
0.349 No Hit 0.0% —
3816 KP13_02227 Outer membrane usher protein fimD fimD AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. +25 total
0.349 No Hit 0.0% —
3817 KP13_01607 YebG family protein AlphaFold + ColabFold – – 0.349 No Hit 0.0% —
3818 KP13_01563 Ribonuclease D rnd AlphaFold + ColabFold
3.1.13.5
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0003676Binding to a nucleic acid. GO:0033890Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides. +69 total
0.349 Hit 25.5% 6.64e-10
3819 KP13_00833 NAGC-like transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006351The synthesis of an RNA transcript from a DNA template.
0.349 Hit 26.5% 5.01e-14
3820 KP13_00282 Cellulose biosynthesis protein BcsF bcsF AlphaFold + ColabFold – – 0.349 No Hit 0.0% —
3821 KP13_31936 aspartyl-tRNA synthetase aspS AlphaFold + ColabFold
6.1.1.12
GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003676Binding to a nucleic acid. +69 total
0.348 Hit 63.0% 1.23e-06
3822 KP13_05510 regulation of transcription, DNA-dependent sugar isomerase domain-containing protein AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.348 No Hit 0.0% —
3823 KP13_03625 hypothetical protein AlphaFold + ColabFold – – 0.348 No Hit 0.0% —
3824 KP13_03412 putative periplasmic binding protein/LacI transcriptional regulator AlphaFold + ColabFold –
GO:0030313An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.348 No Hit 0.0% —
3825 KP13_01529 ABC-type high-affinity branched-chain amino acid transport system livJ AlphaFold + ColabFold –
GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.348 No Hit 0.0% —
Page of 208 · 5192 total proteins