Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3826 KP13_03852 Ethanolamine utilization protein eutA eutA AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0046336The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).
No map 0.854 No Hit 0.0% —
3827 KP13_03856 Alkanesulfonate monooxygenase ssuD AlphaFold DB model + ColabFold model
1.14.14.5
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0008726Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN. GO:0046306The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.
No map 0.615 No Hit 0.0% —
3828 KP13_03857 Putative aliphatic sulfonates-binding protein ssuA AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map 0.671 No Hit 0.0% —
3829 KP13_03858 FMN reductase ssuE AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008752Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. This reaction can utilize NADH and NADPH with similar reaction rates. GO:0046306The chemical reactions and pathways resulting in the breakdown of alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.
No map 0.696 No Hit 0.0% —
3830 KP13_03860 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000917The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. GO:0043093A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells.
No map 0.521 No Hit 0.0% —
3831 KP13_03862 Ribosomal RNA large subunit methyltransferase E rlmL AlphaFold DB model + ColabFold model –
GO:0008990Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +69 total
No map 0.273 No Hit 0.0% —
3832 KP13_03864 Paraquat-inducible protein A pqiA AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.988 No Hit 0.0% —
3833 KP13_03865 Paraquat-inducible protein B pqiB AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.786 No Hit 0.0% —
3834 KP13_03866 putative lipoprotein AlphaFold DB model + ColabFold model – – No map 0.364 No Hit 0.0% —
3835 KP13_03867 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.757 No Hit 0.0% —
3836 KP13_03868 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase fabA AlphaFold DB model + ColabFold model
4.2.1.59 5.3.3.14
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0008693OBSOLETE. Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O. +36 total
No map 0.288 No Hit 0.0% —
3837 KP13_03869 putative protease La AlphaFold DB model + ColabFold model
3.4.21.53
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0030163The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. GO:0004176Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. +25 total
No map 0.16 No Hit 0.0% —
3838 KP13_03870 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map 0.142 No Hit 0.0% —
3839 KP13_03871 Outer membrane protein A ompA AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. +36 total
No map 0.361 No Hit 0.0% —
3840 KP13_03872 hypothetical protein ColabFold model – – No map 0.624 No Hit 0.0% —
3841 KP13_03873 Cell division inhibitor sulA sulA AlphaFold DB model + ColabFold model –
GO:0009432An error-prone process for repairing damaged microbial DNA. GO:0051782Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. GO:0000917The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. +14 total
No map 0.566 No Hit 0.0% —
3842 KP13_03874 Protein sxy sxy AlphaFold DB model + ColabFold model –
GO:0030420The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.
No map 0.175 No Hit 0.0% —
3843 KP13_03875 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.467 No Hit 0.0% —
3844 KP13_03876 Inner membrane protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.859 No Hit 0.0% —
3845 KP13_03877 Helicase IV helD AlphaFold DB model + ColabFold model
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
No map 0.491 No Hit 0.0% —
3846 KP13_03878 Methylglyoxal synthase mgsA AlphaFold DB model + ColabFold model
4.2.3.3
GO:0008929Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate. GO:0019242The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.355 No Hit 0.0% —
3847 KP13_03879 NAD(P)-binding domain-containing protein Experimental + AlphaFold DB model + ColabFold model – – No map 0.482 No Hit 0.0% —
3848 KP13_03880 Heat shock protein hspQ hspQ AlphaFold DB model + ColabFold model –
GO:0009408Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.221 No Hit 0.0% —
3849 KP13_03881 Ribosomal RNA large subunit methyltransferase I rlmI AlphaFold DB model + ColabFold model
2.1.1.191
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +25 total
No map 0.372 No Hit 0.0% —
3850 KP13_03882 phosphatidylethanolamine-binding protein AlphaFold DB model + ColabFold model – – No map 0.482 No Hit 0.0% —
Page of 234 · 5842 total proteins