Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3976 KP13_03553 hypothetical protein ColabFold – – 0.392 No Hit 0.0% —
3977 KP13_03090 hypothetical protein AlphaFold + ColabFold – – 0.392 No Hit 0.0% —
3978 KP13_02683 hypothetical protein ColabFold – – 0.392 No Hit 0.0% —
3979 KP13_02663 hypothetical protein AlphaFold + ColabFold – – 0.392 No Hit 0.0% —
3980 KP13_01399 hypothetical protein AlphaFold + ColabFold – – 0.392 No Hit 0.0% —
3981 KP13_01379 hypothetical protein AlphaFold + ColabFold – – 0.392 No Hit 0.0% —
3982 KP13_01378 DNA-binding protein HU-alpha hupA AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.392 No Hit 0.0% —
3983 KP13_01020 Amidophosphoribosyltransferase purF AlphaFold + ColabFold
2.4.2.14
GO:0009113The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0004044Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.392 Hit 40.3% 5.36e-20
3984 KP13_31540 Aspartate--ammonia ligase asnA AlphaFold + ColabFold
6.3.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004071Catalysis of the reaction: ATP + L-aspartate + NH4+ = AMP + diphosphate + L-asparagine. GO:0006529OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. +36 total
0.391 No Hit 0.0% —
3985 KP13_05115 Oligopeptide ABC transport system permease component AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.391 No Hit 0.0% —
3986 KP13_04881 Transaldolase 1 AlphaFold + ColabFold
2.2.1.2
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004801Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. +25 total
0.391 Hit 58.2% 1.05e-20
3987 KP13_04575 Putative metabolite transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.391 Hit 28.3% 1.93e-09
3988 KP13_04471 putative hydrolase AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0047372Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+. GO:0046464The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.
0.391 Hit 50.0% 1.46e-07
3989 KP13_04260 Glutaredoxin-1 grxA AlphaFold + ColabFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0015035Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. +47 total
0.391 Hit 32.1% 1.21e-07
3990 KP13_03475 Helix-turn-helix type 3 domain-containing protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.391 No Hit 0.0% —
3991 KP13_02115 branched-chain amino-acid ABC transport system periplasmic binding protein AlphaFold + ColabFold – – 0.391 No Hit 0.0% —
3992 KP13_01468 putative sulfate transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008272OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.391 Hit 35.2% 8.40e-23
3993 KP13_14111 3-dehydroquinate dehydratase aroD AlphaFold + ColabFold
4.2.1.10
GO:0003855Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. GO:0046279The chemical reactions and pathways resulting in the formation of 3,4-dihydroxybenzoate. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. +25 total
0.39 No Hit 0.0% —
3994 KP13_06699 putative replication protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
0.39 No Hit 0.0% —
3995 KP13_05483 urate catabolism protein AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.39 No Hit 0.0% —
3996 KP13_04422 Electron transport complex protein rnfA rnfA AlphaFold + ColabFold
7.-.-.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. GO:0012505A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. +14 total
0.39 No Hit 0.0% —
3997 KP13_03999 Protease degQ degQ AlphaFold + ColabFold
3.4.21.107
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +25 total
0.39 Hit 41.4% 8.32e-29
3998 KP13_02046 Riboflavin biosynthesis bifunctional protein ribD ribD AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0008835Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O + H+ = 5-amino-6-(5-phosphoribosylamino)uracil + NH4. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +47 total
0.39 No Hit 0.0% —
3999 KP13_01314 hypothetical protein ColabFold – – 0.39 No Hit 0.0% —
4000 KP13_31955 putative glutathione peroxidase AlphaFold + ColabFold –
GO:0004602Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
0.389 Hit 53.9% 4.11e-18
Page of 234 · 5842 total proteins