Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4176 KP13_31583 putative ABC transporter AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.363 Hit 34.6% 1.01e-12
4177 KP13_02261 Putative ABC transporter substrate-binding protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.363 No Hit 0.0% —
4178 KP13_02087 Pyrroline-5-carboxylate reductase proC AlphaFold + ColabFold
1.5.1.2
GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. GO:0004735Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.363 Hit 50.6% 1.03e-19
4179 KP13_01519 ABC transporter, periplasmic substrate-binding protein AlphaFold + ColabFold –
GO:0030973Binding to a molybdate ion (MoO4 2-). GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
0.363 No Hit 0.0% —
4180 KP13_00688 Transcriptional regulatory protein ompR ompR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
0.363 No Hit 0.0% —
4181 KP13_06679 hypothetical protein AlphaFold + ColabFold – – 0.362 No Hit 0.0% —
4182 KP13_05464 hypothetical protein ColabFold – – 0.362 No Hit 0.0% —
4183 KP13_05041 3-oxoadipate CoA-transferase subunit B pcaJ AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.362 Hit 44.7% 1.22e-53
4184 KP13_03606 HTH-type transcriptional regulator CueR cueR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.362 No Hit 0.0% —
4185 KP13_03349 Protein crcB crcB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0062054Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel. +25 total
0.362 No Hit 0.0% —
4186 KP13_02482 2-dehydro-3-deoxygalactonokinase AlphaFold + ColabFold –
GO:0008671Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+. GO:0034194The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.
0.362 No Hit 0.0% —
4187 KP13_05411 NADP-specific glutamate dehydrogenase gdhA AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016639Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +47 total
0.361 Hit 31.8% 4.71e-17
4188 KP13_04970 Phenylacetic acid degradation protein paaD paaD AlphaFold + ColabFold – – 0.361 No Hit 0.0% —
4189 KP13_04833 Protein mtfA mtfA Experimental + ColabFold –
GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.361 No Hit 0.0% —
4190 KP13_04489 hypothetical protein AlphaFold + ColabFold – – 0.361 No Hit 0.0% —
4191 KP13_03871 Outer membrane protein A ompA AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. +36 total
0.361 No Hit 0.0% —
4192 KP13_03436 putative ABC transport system ATP-binding component AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.361 Hit 51.0% 1.33e-07
4193 KP13_03368 putative ABC transporter AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.361 Hit 35.0% 2.22e-07
4194 KP13_01846 General secretion pathway protein M pulM AlphaFold + ColabFold –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.361 No Hit 0.0% —
4195 KP13_31971 hypothetical protein AlphaFold + ColabFold – – 0.36 No Hit 0.0% —
4196 KP13_05077 GNAT family acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.36 No Hit 0.0% —
4197 KP13_04937 DNA-damage-inducible protein I AlphaFold + ColabFold –
GO:0009432An error-prone process for repairing damaged microbial DNA.
0.36 No Hit 0.0% —
4198 KP13_02983 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.36 No Hit 0.0% —
4199 KP13_01608 Phosphoribosylglycinamide formyltransferase 2 purT AlphaFold + ColabFold
6.3.1.21
GO:0009152The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0046872Binding to a metal ion. GO:0004644Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. +69 total
0.36 No Hit 0.0% —
4200 KP13_01523 Phosphoenolpyruvate carboxykinase ATP AlphaFold + ColabFold
4.1.1.49
GO:0017076Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. +47 total
0.36 No Hit 0.0% —
Page of 234 · 5842 total proteins