Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4201 KP13_01837 General secretion pathway protein D pulD Experimental + AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. +36 total
No map 0.233 0.395 No Hit 0.0% —
4202 KP13_05340 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.232 No Hit 0.0% —
4203 KP13_02578 Formate hydrogenlyase subunit 7 hycG AlphaFold DB model + ColabFold model –
GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +25 total
No map 0.232 0.429 Hit 37.1% 9.65e-28
4204 KP13_31626 Ribosomal large subunit pseudouridine synthase D rluD AlphaFold DB model + ColabFold model –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0001522The intramolecular conversion of uridine to pseudouridine within an RNA molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. +14 total
No map 0.231 0.433 Hit 43.4% 3.94e-06
4205 KP13_04424 OriC-binding nucleoid-associated protein cnu AlphaFold DB model + ColabFold model – – No map N/A 0.231 No Hit 0.0% —
4206 KP13_02838 glycerol dehydratase medium subunit dhaC Experimental + ColabFold model
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
No map 0.231 0.803 No Hit 0.0% —
4207 KP13_00603 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.231 0.28 No Hit 0.0% —
4208 KP13_31952 putative transposase AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
No map 0.230 0.223 No Hit 0.0% —
4209 KP13_31881 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.23 No Hit 0.0% —
4210 KP13_05054 GTP cyclohydrolase 1 folE AlphaFold DB model + ColabFold model
3.5.4.16
GO:0003934Catalysis of the reaction: GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H+. GO:0046654The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.230 0.425 Hit 36.0% 2.62e-34
4211 KP13_04841 hypothetical protein AlphaFold DB model + ColabFold model
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate. +47 total
No map 0.230 0.9 No Hit 0.0% —
4212 KP13_00853 Protein sseB sseB AlphaFold DB model + ColabFold model – – No map 0.230 0.528 No Hit 0.0% —
4213 KP13_00700 hypothetical protein ColabFold model – – No map N/A 0.23 No Hit 0.0% —
4214 KP13_06637 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.229 No Hit 0.0% —
4215 KP13_05310 Cytochrome c biogenesis ATP-binding export protein CcmA ccmA AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +14 total
No map 0.229 0.111 Hit 33.5% 2.27e-12
4216 KP13_04663 Vitamin B12 import ATP-binding protein btuD btuD AlphaFold DB model + ColabFold model
7.6.2.8
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015889The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.229 0.823 Hit 29.9% 1.20e-07
4217 KP13_02913 Xanthine phosphoribosyltransferase gpt AlphaFold DB model + ColabFold model
2.4.2.22
GO:0000310Catalysis of the reaction: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +710 total
No map 0.229 0.257 No Hit 0.0% —
4218 KP13_02082 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.229 No Hit 0.0% —
4219 KP13_00342 Cell division ATP-binding protein ftsE ftsE AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +25 total
No map 0.229 0.485 Hit 34.2% 7.25e-25
4220 KP13_05969 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.228 No Hit 0.0% —
4221 KP13_05493 putative HTH-type transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.228 0.772 No Hit 0.0% —
4222 KP13_04426 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.228 No Hit 0.0% —
4223 KP13_04143 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.228 No Hit 0.0% —
4224 KP13_02549 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.228 0.54 No Hit 0.0% —
4225 KP13_00431 Cation/acetate symporter actP actP AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015123Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +69 total
No map 0.228 0.766 Hit 26.2% 1.57e-07
Page of 234 · 5842 total proteins