Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4226 KP13_04351 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.227 0.596 No Hit 0.0% —
4227 KP13_04023 Phage portal protein AlphaFold DB model + ColabFold model – – No map 0.227 0.74 No Hit 0.0% —
4228 KP13_04018 hypothetical protein ColabFold model – – No map N/A 0.227 No Hit 0.0% —
4229 KP13_01467 Ribose-phosphate pyrophosphokinase prs AlphaFold DB model + ColabFold model
2.7.6.1
GO:0009156The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar. GO:0004749Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+. GO:0009165The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). +811 total
No map 0.227 0.325 Hit 59.3% 2.47e-19
4230 KP13_01365 Diguanylate cyclase domain-containing protein AlphaFold DB model + ColabFold model
2.7.7.65
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. GO:0005525Binding to GTP, guanosine triphosphate.
No map 0.227 0.785 No Hit 0.0% —
4231 KP13_05218 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.226 No Hit 0.0% —
4232 KP13_03764 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004029Catalysis of the reaction: an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH.
No map 0.226 0.563 No Hit 0.0% —
4233 KP13_03113 putative periplasmic protein AlphaFold DB model + ColabFold model – – No map 0.226 0.942 No Hit 0.0% —
4234 KP13_00789 hypothetical protein ColabFold model – – No map N/A 0.226 No Hit 0.0% —
4235 KP13_00520 Putative ribosome biogenesis GTPase RsgA rsgA AlphaFold DB model + ColabFold model
3.6.1.-
GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. GO:0005525Binding to GTP, guanosine triphosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
No map 0.226 0.703 No Hit 0.0% —
4236 KP13_31548 Formate hydrogenlyase transcriptional activator fhlA AlphaFold DB model + ColabFold model –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +47 total
No map 0.225 0.461 No Hit 0.0% —
4237 KP13_06679 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.225 0.362 No Hit 0.0% —
4238 KP13_05484 Sulfite exporter TauE family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.225 0.592 No Hit 0.0% —
4239 KP13_04421 Electron transport complex protein rnfB rnfB AlphaFold DB model + ColabFold model
7.-.-.-
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. +36 total
No map 0.225 0.369 No Hit 0.0% —
4240 KP13_04060 putative transposase ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.225 0.049 No Hit 0.0% —
4241 KP13_03423 hypothetical protein ColabFold model – – No map N/A 0.225 No Hit 0.0% —
4242 KP13_01833 General secretion pathway protein B AlphaFold DB model + ColabFold model –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.
No map N/A 0.225 No Hit 0.0% —
4243 KP13_01715 Magnesium transport protein corA corA AlphaFold DB model + ColabFold model –
GO:0015087Enables the transfer of cobalt (Co2+) ions from one side of a membrane to the other. GO:0015693The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015095Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. +710 total
No map 0.225 0.763 No Hit 0.0% —
4244 KP13_00346 4-aminobutyrate aminotransferase puuE Experimental + ColabFold model –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0003867OBSOLETE. Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. +47 total
No map 0.225 0.076 Hit 33.1% 3.02e-15
4245 KP13_04465 Inner membrane ABC transporter permease protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.224 0.845 No Hit 0.0% —
4246 KP13_03718 HTH-type transcriptional regulator mlrA mlrA AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.224 0.043 No Hit 0.0% —
4247 KP13_03111 putative transposase AlphaFold DB model + ColabFold model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.224 No Hit 0.0% —
4248 KP13_02999 Molybdenum transport system permease protein modB modB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0015098Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. +25 total
No map 0.224 0.838 No Hit 0.0% —
4249 KP13_05436 Peptide transport system ATP-binding protein sapF sapF AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.223 0.201 Hit 33.3% 1.48e-06
4250 KP13_01651 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.223 0.542 No Hit 0.0% —
Page of 234 · 5842 total proteins