Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4251 KP13_01914 Protein mraZ mraZ AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.272 No Hit 0.0% —
4252 KP13_01598 Serine/threonine-protein phosphatase 1 AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.272 No Hit 0.0% —
4253 KP13_00316 Nickel-responsive regulator nikR AlphaFold + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0010045Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. +36 total
0.272 No Hit 0.0% —
4254 KP13_04317 C4-type zinc finger protein, DksA/TraR family AlphaFold + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:1900378Any process that activates or increases the frequency, rate or extent of secondary metabolite biosynthetic process.
0.271 No Hit 0.0% —
4255 KP13_03262 hypothetical protein AlphaFold + ColabFold – – 0.271 No Hit 0.0% —
4256 KP13_01963 hypothetical protein AlphaFold + ColabFold – – 0.271 No Hit 0.0% —
4257 KP13_01958 Protein apaG apaG AlphaFold + ColabFold –
GO:0070987The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
0.271 Hit 43.2% 2.11e-12
4258 KP13_01430 Tryptophanyl-tRNA synthetase AlphaFold + ColabFold – – 0.271 Hit 26.2% 8.32e-07
4259 KP13_00691 hypothetical protein AlphaFold + ColabFold – – 0.271 No Hit 0.0% —
4260 KP13_00303 putative iron-containing alcohol dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. GO:0004022Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
0.271 Hit 27.5% 7.33e-15
4261 KP13_05136 Riboflavin synthase alpha chain ribE AlphaFold + ColabFold
2.5.1.9
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004746Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H+ = 5-amino-6-(D-ribitylamino)uracil + riboflavin. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
0.27 No Hit 0.0% —
4262 KP13_04505 putative ABC transport system substrate-binding component AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015408Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.27 Hit 50.0% 1.02e-06
4263 KP13_03916 protein rutD rutD AlphaFold + ColabFold –
GO:0006212The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.
0.27 Hit 28.4% 4.27e-06
4264 KP13_02708 Short-chain dehydrogenase/reductase family protein AlphaFold + ColabFold – – 0.27 Hit 39.1% 2.50e-07
4265 KP13_02490 Homoprotocatechuate degradative operon repressor hpcR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045892Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +25 total
0.27 No Hit 0.0% —
4266 KP13_02332 Cobalt-precorrin-3B C(17)-methyltransferase cbiH AlphaFold + ColabFold –
GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0032259The process in which a methyl group is covalently attached to a molecule.
0.27 No Hit 0.0% —
4267 KP13_02225 Protein fimG fimG AlphaFold + ColabFold –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
0.27 No Hit 0.0% —
4268 KP13_00418 Glutathione S-transferase 1 AlphaFold + ColabFold – – 0.27 Hit 25.3% 1.19e-06
4269 KP13_04858 Excisionase-like protein from lambdoid prophage 14 xisE AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.269 No Hit 0.0% —
4270 KP13_03226 Enhancing lycopene biosynthesis protein 2 elbB AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.269 Hit 54.8% 8.90e-31
4271 KP13_05491 hypothetical protein AlphaFold + ColabFold – – 0.268 No Hit 0.0% —
4272 KP13_05429 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.268 No Hit 0.0% —
4273 KP13_04778 hypothetical protein AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +58 total
0.268 No Hit 0.0% —
4274 KP13_02702 Peptidyl-prolyl cis-trans isomerase C AlphaFold + ColabFold
5.2.1.8
GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.268 Hit 45.1% 2.17e-17
4275 KP13_02350 Ribosomal RNA large subunit methyltransferase M rlmM AlphaFold + ColabFold
2.1.1.186
GO:0032259The process in which a methyl group is covalently attached to a molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.268 No Hit 0.0% —
Page of 208 · 5192 total proteins